ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2007
In vivo histopathology for detection of gastrointestinal neoplasia with a portable, confocal miniprobe: an examiner blinded analysis.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01563133 (Clinical Evaluation Of NCLE in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Evaluation Of NCLE in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis.BioMed research international · 2016Pooled it
- Probe-based confocal laser microscopy identifies criteria predictive of active celiac sprue.Digestive diseases and sciences · 2012Trial
- Real-time increased detection of neoplastic tissue in Barrett's esophagus with probe-based confocal laser endomicroscopy: final results of an international multicenter, prospective, randomized, controlled trial.Gastrointestinal endoscopy · 2011Trial
- Results of a phase I-II study on intraductal confocal microscopy (IDCM) in patients with common bile duct (CBD) stenosis.Surgical endoscopy · 2011Trial
- Confocal laser endomicroscopy in Barrett's esophagus and endoscopically inapparent Barrett's neoplasia: a prospective, randomized, double-blind, controlled, crossover trial.Gastrointestinal endoscopy · 2009Trial
- Diagnosis of Cholangiocarcinoma: The New Biological and Technological Horizons.Diagnostics (Basel, Switzerland) · 2025Review
- The Role of Cholangioscopy in Biliary Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Development, Implementation and Application of Confocal Laser Endomicroscopy in Brain, Head and Neck Surgery-A Review.Diagnostics (Basel, Switzerland) · 2022Review
- Endoscopic Evaluation of Biliary Strictures: Current and Emerging Techniques.Clinical endoscopy · 2021Review
- Confocal Laser Endomicroscopy in Oncological Surgery.Diagnostics (Basel, Switzerland) · 2021Article
- Optical biopsy in gastroenterology: Focus on confocal laser endomicroscopy.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- A study on confocal endomicroscopy in comparison with histopathology for polypoidal lesions of the gastrointestinal tract: A prospective single-centre experience.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Observational
- Probe-based confocal endomicroscopy is accurate for differentiating gastric lesions in patients in a Western center.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2018Article
- Multispectral light scattering endoscopic imaging of esophageal precancer.Light, science & applications · 2018Article
- Implementation of real-time probe-based confocal laser endomicroscopy (pCLE) for differentiation of colorectal polyps during routine colonoscopy.Endoscopy international open · 2017Article
- Probe-based confocal laser endomicroscopy for evaluating the submucosal invasion of colorectal neoplasms.Surgical endoscopy · 2017Article
- Noninvasive histological imaging of head and neck squamous cell carcinomas using confocal laser endomicroscopy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Application and Efficacy of Super-Magnifying Endoscopy for the Lower Intestinal Tract.Clinical endoscopy · 2016Review
- Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence.United European gastroenterology journal · 2015Review
- Diagnosis and management of primary sclerosing cholangitis-perspectives from a therapeutic endoscopist.World journal of hepatology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsConfocal fluorescence microscopy (CFM) has been mentioned to be a promising tool for in vivo histology. Recently, a portable confocal miniprobe has been developed. Our aim was to evaluate the potential benefit of CFM for detection of gastrointestinal neoplasia.
methodsA total of 47 patients with known or suspected neoplasia in the upper (n = 34) or lower gastrointestinal tract (n = 13) were examined with standard endoscopes. After mucolyis with 5-10 mL of acetic acid 1.5%, chromoendoscopy with 2-5 mL cresyl violet 0.25% was performed, with the substance also being used as a fluorophore for CFM. Real-time video sequences were recorded. Thereafter, biopsies were taken or mucosectomy/polypectomy was performed from the same examined area. All stored sequences were put into a random order and assessed by a pathologist and a gastroenterologist both blinded to any data.
resultsA total of 119 CFM video sequences were recorded of 85 benign or 34 neoplastic areas. Quality of CFM images was regarded too low in 24 (pathologist) and 14 sequences (gastroenterologist). For the pathologist, accuracy of CFM detecting neoplasia was 92.6% (suitable images) and 73.9% (intention to diagnose). The respective accuracy values for the gastroenterologist were 92.4% (suitable images) and 81.5% (intention to diagnose). Agreement between CFM and histopathology was excellent (kappa values, 0.821 and 0.817).
conclusionsWe have demonstrated that CFM with a miniprobe has the potential to diagnose neoplasia during ongoing endoscopy. This system has the advantage that it can be used with standard endoscopes. Further studies are warranted for validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.