ArticleBMC infectious diseases2007
Identification of diarrheagenic Escherichia coli isolated from infants and children in Dar es Salaam, Tanzania.
Article in BMC infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 181 citations in OpenAlex.
- Childhood diarrhoea attributed to enteropathogenic bacteria in low- and middle-income countries: a systematic review and meta-analysis.Journal of global health · 2025Pooled it
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- Antibiotic Resistance Profile of EnterovirulentInternational journal of microbiology · 2025Article
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- Resistance Profiles and Virulence Factors of EntericInternational journal of microbiology · 2025Article
- Review
- Extended-spectrum beta-lactamase (ESBL)- and non-ESBL producing Escherichia coli surveillance in surface water sources in Edo State, Nigeria: a public health concern.Scientific reports · 2024Article
- Diarrhoeagenic Escherichia coli associated with childhood diarrhoea in Osun state, Nigeria.BMC infectious diseases · 2024Article
- Molecular Characterization of Hetero-Pathogenic and DiarrheagenicPathogens (Basel, Switzerland) · 2023Article
- Prevalence and Molecular Characterization of Shiga Toxin-ProducingPathogens (Basel, Switzerland) · 2023Article
- Site specific incidence rate of genomic subtypes of enteropathogenic Escherichia coli and association with enteric inflammation and child growth.Scientific reports · 2022Article
- Antimicrobial Resistance, Pathogenic, and Molecular Characterization ofPathogens (Basel, Switzerland) · 2022Article
- DiarrhoeagenicAfrican health sciences · 2022Article
- Molecular Characterization and Antimicrobial Resistance of PathogenicJournal of tropical medicine · 2022Article
- Culture independent DNA extraction method for bacterial cells concentrated from water.MethodsX · 2022Article
- Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children.Scientific reports · 2021Article
- Typical and atypical enteropathogenic Escherichia coli in children with acute diarrhoea: Changing trend in East Delhi.Biomedical journal · 2021Article
- The first evaluation relationship of integron genes and the multidrug-resistance in class A ESBLs genes in enteropathogenic Escherichia coli strains isolated from children with diarrhea in Southwestern Iran.Molecular biology reports · 2021Article
- Molecular Epidemiology of EnteroaggregativeInternational journal of molecular sciences · 2020Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRelatively few studies have been done in Tanzania to detect and classify diarrheagenic Escherichia coli (DEC) strains among children with diarrhea. This study aimed at investigating DEC among children in Dar es Salaam aged less than five years hospitalized due to acute/persistent diarrhea.
methodsDEC were isolated from stool samples collected from two hundred and eighty children with acute/persistent diarrhea at Muhimbili National Hospital and Ilala and Mwananyamala Municipal Hospitals in Dar es Salaam. A multiplex PCR system method was used to detect a species specific gene for E.coli and ten different virulence genes for detection of five pathogroups of DEC namely enteroaggregative- (EAEC), enteropathogenic- (EPEC), enterotoxigenic- (ETEC), enteroinvasive- (EIEC) and enterohemorghagic- Escherichia coli (EHEC).
resultsSixty-four patients (22.9%) harbored DEC. Forty-one of them (14.6%) were categorized as EAEC. Most of the EAEC (82.9%) were classified as typical EAEC possessing the aggR gene, and 92.6% carried the aat gene. Isolates from thirteen patients were EPEC (4.6%) and most of these (92.3%) were typical EPEC with both eae and bfpA genes. Ten isolates were identified as ETEC (3.6%) with only the heat stable toxin; either st1a or st1b but not both. Age wise, EAEC and EPEC were significantly more prevalent among the age group 0-6 months (p < 0.05). Genes for EHEC (stx1 and stx2) and EIEC (ial) were not detected in this study group.
conclusionThe results show a high proportion of DEC among Tanzanian children with diarrhea, with typical EAEC and typical EPEC predominating. The use of primers for both variants of ST1 (st1a and st1b) increased the sensitivity for detection of ETEC strains.
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