ArticleBiometrics2007
Statistical tests for clonality.
Article in Biometrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Analysis of Shared Variants between Cancer Biospecimens.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Pattern and risk factors of isolated local relapse among women with hormone receptor-positive and HER2-negative breast cancer and lymph node involvement: 10-year follow-up analysis of the PACS 01 and PACS 04 trials.Breast cancer research and treatment · 2023Article
- [Research Progress in Distinguishing Methods of Simultaneous Multiple Primary Lung Cancer and Intrapulmonary Metastasis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021Review
- Testing tumors from different anatomic sites for clonal relatedness using somatic mutation data.Biometrics · 2021Article
- Molecular Identification and Genetic Characterization of Early-Stage Multiple Primary Lung Cancer by Large-Panel Next-Generation Sequencing Analysis.Frontiers in oncology · 2021Article
- Comparative mutational evaluation of multiple lung cancers by multiplex oncogene mutation analysis.Cancer science · 2018Article
- Clonal relatedness in tumour pairs of breast cancer patients.Breast cancer research : BCR · 2018Article
- Estimating the probability of clonal relatedness of pairs of tumors in cancer patients.Biometrics · 2018Article
- Comprehensive Genomic Profiling Aids in Distinguishing Metastatic Recurrence from Second Primary Cancers.The oncologist · 2017Article
- Comparative genomic analysis reveals bilateral breast cancers are genetically independent.Oncotarget · 2015Article
- USING SOMATIC MUTATION DATA TO TEST TUMORS FOR CLONAL RELATEDNESS.The annals of applied statistics · 2015Article
- DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors.BMC cancer · 2015Article
- Mutational Profiling Can Establish Clonal or Independent Origin in Synchronous Bilateral Breast and Other Tumors.PloS one · 2015Article
- Dissecting the clonal origins of childhood acute lymphoblastic leukemia by single-cell genomics.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Testing clonality of three and more tumors using their loss of heterozygosity profiles.Statistical applications in genetics and molecular biology · 2012Review
- Clonality: an R package for testing clonal relatedness of two tumors from the same patient based on their genomic profiles.Bioinformatics (Oxford, England) · 2011Article
- A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data.Statistics in medicine · 2010Article
- Testing clonal relatedness of tumors using array comparative genomic hybridization: a statistical challenge.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Evaluation of the clonal origin of multiple primary melanomas using molecular profiling.The Journal of investigative dermatology · 2009Article
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3 authors at 1 institution in 1 country.
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Abstract
Cancer investigators frequently conduct studies to examine tumor samples from pairs of apparently independent primary tumors with a view to determine whether they share a "clonal" origin. The genetic fingerprints of the tumors are compared using a panel of markers, often representing loss of heterozygosity (LOH) at distinct genetic loci. In this article we evaluate candidate significance tests for this purpose. The relevant information is derived from the observed correlation of the tumors with respect to the occurrence of LOH at individual loci, a phenomenon that can be evaluated using Fisher's exact test. Information is also available from the extent to which losses at the same locus occur on the same parental allele. Data from these combined sources of information can be evaluated using a simple adaptation of Fisher's exact test. The test statistic is the total number of loci at which concordant mutations occur on the same parental allele, with higher values providing more evidence in favor of a clonal origin for the two tumors. The test is shown to have high power for detecting clonality for plausible models of the alternative (clonal) hypothesis, and for reasonable numbers of informative loci, preferably located on distinct chromosomal arms. The method is illustrated using studies to identify clonality in contralateral breast cancer. Interpretation of the results of these tests requires caution due to simplifying assumptions regarding the possible variability in mutation probabilities between loci, and possible imbalances in the mutation probabilities between parental alleles. Nonetheless, we conclude that the method represents a simple, powerful strategy for distinguishing independent tumors from those of clonal origin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.