ArticleParasitology research2007
Translationally controlled tumor protein of Brugia malayi functions as an antioxidant protein.
Article in Parasitology research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Potential of histamine release factor for the utilization as a universal vaccine antigen against poultry red mites, tropical fowl mites, and northern fowl mites.The Journal of veterinary medical science · 2025Article
- Sequence Analysis and Comparison of TCTP Proteins from Human Protozoan Parasites.Acta parasitologica · 2022Article
- Article
- Radiosensitivity of Cancer Cells Is Regulated by Translationally Controlled Tumor Protein.Cancers · 2019Article
- Assessment of the role of translationally controlled tumor protein 1 (TPT1/TCTP) in breast cancer susceptibility and ATM signaling.Clinical and translational radiation oncology · 2019Article
- The translationally controlled tumor protein TCTP is involved in cell cycle progression and heat stress response in the bloodstream form ofMicrobial cell (Graz, Austria) · 2018Article
- Distinct 3' UTRs regulate the life-cycle-specific expression of twoJournal of cell science · 2018Article
- Vaccination Against Whipworm: Identification of Potential Immunogenic Proteins in Trichuris muris Excretory/Secretory Material.Scientific reports · 2018Article
- Responses of Antioxidant Defense and Immune Gene Expression in Early Life Stages of Large Yellow Croaker (Frontiers in physiology · 2018Article
- Effect of novel chitosan-fluoroaluminosilicate resin modified glass ionomer cement supplemented with translationally controlled tumor protein on pulp cells.Journal of materials science. Materials in medicine · 2014Article
- Role of the translationally controlled tumor protein in DNA damage sensing and repair.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Sumoylation of human translationally controlled tumor protein is important for its nuclear transport.Biochemistry research international · 2012Article
- Biological effects of Mammalian translationally controlled tumor protein (TCTP) on cell death, proliferation, and tumorigenesis.Biochemistry research international · 2012Article
- Translationally controlled tumor protein against apoptosis from 2-hydroxy-ethyl methacrylate in human dental pulp cells.Journal of materials science. Materials in medicine · 2011Article
- Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src.Oncogene · 2011Article
- Identification and characterization of genes associated with tapping panel dryness from Hevea brasiliensis latex using suppression subtractive hybridization.BMC plant biology · 2010Article
- Article
- Translationally controlled tumor protein is a novel heat shock protein with chaperone-like activity.Biochemical and biophysical research communications · 2009Article
- Transcriptome analysis of Schistosoma mansoni larval development using serial analysis of gene expression (SAGE).Parasitology · 2009Article
- Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Translationally controlled tumor protein (TCTP) is one of the most abundantly expressed proteins in the filarial parasites as well as in the other organisms. Several functions have been suggested for TCTP family of proteins ranging from calcium binding to histamine release function. However, its physiological function is still a mystery. Previous studies showed that the expression of TCTP is increased several-fold during oxidative stress. In the present work, we report the putative antioxidant function of Brugia malayi TCTP (BmTCTP). When tested in vitro, rBmTCTP could be reduced by a variety of reducing agents including thioredoxin. Such reduced form of rBmTCTP was able to protect DNA from oxidative damage, suggesting that BmTCTP may have an antioxidant function in the parasite. Sequence analysis of filarial TCTPs revealed that there are three cysteine amino acids located in the central portion of the protein. Subsequent targeted residue modification studies showed that these cysteine residues in rBmTCTP are critical for its antioxidant function. To determine the significance of this finding, rBmTCTP was overexpressed in vivo in Escherichia coli and subjected to oxidative stress. These studies showed that rBmTCTP significantly protected cells form oxidative damage. Taken together, these findings suggest that BmTCTP might be functioning as a non-classical antioxidant protein in the filarial parasites.
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