ArticleThe Journal of investigative dermatology2008
Involvement of dynein and spectrin with early melanosome transport and melanosomal protein trafficking.
Article in The Journal of investigative dermatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Critical role of alpha spectrin in DNA repair: the importance of μ-calpain and Fanconi anemia proteins.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Integrin-linked kinase regulates melanosome trafficking and melanin transfer in melanocytes.Molecular biology of the cell · 2020Article
- Comparative Transcriptome Analysis of Raccoon Dog Skin to Determine Melanin Content in Hair and Melanin Distribution in Skin.Scientific reports · 2017Article
- LASP1, a Newly Identified Melanocytic Protein with a Possible Role in Melanin Release, but Not in Melanoma Progression.PloS one · 2015Article
- Skin melanocytes: biology and development.Postepy dermatologii i alergologii · 2013Review
- βIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex.The Journal of biological chemistry · 2013Article
- Fodrin in centrosomes: implication of a role of fodrin in the transport of gamma-tubulin complex in brain.PloS one · 2013Article
- Computational prediction of protein-protein interactions of human tyrosinase.Enzyme research · 2012Article
- Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.Neuron · 2011Article
- Update on the regulation of mammalian melanocyte function and skin pigmentation.Expert review of dermatology · 2011Article
- The deceptive nature of UVA tanning versus the modest protective effects of UVB tanning on human skin.Pigment cell & melanoma research · 2011Article
- Changes in localization and expression levels of Shroom2 and spectrin contribute to variation in amphibian egg pigmentation patterns.Development genes and evolution · 2009Article
- Missense mutation in exon 2 of SLC36A1 responsible for champagne dilution in horses.PLoS genetics · 2008Article
- Physiological factors that regulate skin pigmentation.BioFactors (Oxford, England)Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Melanosomes are unique membrane-bound organelles specialized for the synthesis and distribution of melanin. Mechanisms involved in the trafficking of proteins to melanosomes and in the transport of mature pigmented melanosomes to the dendrites of melanocytic cells are being characterized, but details about those processes during early stages of melanosome maturation are not well understood. Early melanosomes must remain in the perinuclear area until critical components are assembled. In this study, we characterized the processing of two distinct melanosomal proteins, tyrosinase (TYR) and Pmel17, to elucidate protein processing in early or late steps of the secretory pathway, respectively, and to determine mechanisms underlying the subcellular localization and transport of early melanosomes. We used immunological, biochemical, and molecular approaches to demonstrate that the movement of early melanosomes in the perinuclear area depends primarily on microtubules but not on actin filaments. In contrast, the trafficking of TYR and Pmel17 depends on cytoplasmic dynein and its interaction with the spectrin/ankyrin system, which is involved with the sorting of cargo from the plasma membrane. These results provide important clues toward understanding the processes involved with early events in melanosome formation and transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.