ArticleNature2007
Crystallography: crystallographic evidence for deviating C3b structure.
Article in Nature, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Communities in structural biology.Nature structural & molecular biology · 2024Article
- New tools in MolProbity validation: CaBLAM for CryoEM backbone, UnDowser to rethink "waters," and NGL Viewer to recapture online 3D graphics.Protein science : a publication of the Protein Society · 2020Article
- A Visualization Tool for Cryo-EM Protein Validation with an Unsupervised Machine Learning Model in Chimera Platform.Medicines (Basel, Switzerland) · 2019Article
- New tools for the analysis and validation of cryo-EM maps and atomic models.Acta crystallographica. Section D, Structural biology · 2018Article
- Correcting the record of structural publications requires joint effort of the community and journal editors.The FEBS journal · 2016Article
- Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense.Immunological reviews · 2016Review
- Data publication with the structural biology data grid supports live analysis.Nature communications · 2016Article
- Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.Acta crystallographica. Section D, Biological crystallography · 2015Article
- The solvent component of macromolecular crystals.Acta crystallographica. Section D, Biological crystallography · 2015Review
- An approach to creating a more realistic working model from a protein data bank entry.Journal of molecular modeling · 2015Article
- Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination.The FEBS journal · 2013Review
- Crystallographic model validation: from diagnosis to healing.Current opinion in structural biology · 2013Review
- Acute phase proteins are major clients for the chaperone action of α₂-macroglobulin in human plasma.Cell stress & chaperones · 2013Article
- Detection and analysis of unusual features in the structural model and structure-factor data of a birch pollen allergen.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- A new generation of crystallographic validation tools for the protein data bank.Structure (London, England : 1993) · 2011Article
- PDBWiki: added value through community annotation of the Protein Data Bank.Database : the journal of biological databases and curation · 2010Article
- PROSESS: a protein structure evaluation suite and server.Nucleic acids research · 2010Article
- Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein.The Journal of biological chemistry · 2010Article
- Fraud rocks protein community.Nature · 2009Article
- RosettaHoles: rapid assessment of protein core packing for structure prediction, refinement, design, and validation.Protein science : a publication of the Protein Society · 2009Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Activation of the protein C3 into C3b in the complement pathway is a crucial step in the complement immune response against pathogenic, immunogenic and apoptotic particles. Ajees et al. describe a crystal structure for C3b that deviates from the one reported by Janssen et al. and by Wiesmann et al.. We have reanalysed the data deposited by Ajees et al. and have discovered features that are inconsistent with the known physical properties of macromolecular structures and their diffraction data. Our findings therefore call into question the crystal structure for C3b reported by Ajees et al..
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.