ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2008
Dopamine depletion of the prefrontal cortex induces dendritic spine loss: reversal by atypical antipsychotic drug treatment.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Plasma Orexin-A Levels in Patients With Schizophrenia: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Antioxidant treatments for schizophrenia.The Cochrane database of systematic reviews · 2016Pooled it
- Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Trial
- Time-lapse mapping of cortical changes in schizophrenia with different treatments.Cerebral cortex (New York, N.Y. : 1991) · 2009Trial
- Article
- Olanzapine Ameliorates Ischemic Stroke-like Pathology in Gerbils and HAntioxidants (Basel, Switzerland) · 2022Article
- Review
- Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control.Cells · 2021Review
- Allosteric Modulators of G Protein-Coupled Dopamine and Serotonin Receptors: A New Class of Atypical Antipsychotics.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats.Frontiers in neuroscience · 2020Article
- Inefficient neural system stabilization: a theory of spontaneous resolutions and recurrent relapses in psychosisJournal of psychiatry & neuroscience : JPN · 2019Review
- Microglial Pruning of Synapses in the Prefrontal Cortex During Adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Levodopa treatment and dendritic spine pathology.Movement disorders : official journal of the Movement Disorder Society · 2018Review
- Dopamine Synthesis Capacity is Associated with D2/3 Receptor Binding but Not Dopamine Release.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice.Psychopharmacology · 2017Article
- The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression.Translational psychiatry · 2017Article
- Dopaminergic control of anxiety in young and aged zebrafish.Pharmacology, biochemistry, and behavior · 2017Article
- Differential Associations between Cortical Thickness and Striatal Dopamine in Treatment-Naïve Adults with ADHD vs. Healthy Controls.Frontiers in human neuroscience · 2017Article
- Cortical brain volume abnormalities associated with few or multiple neuropsychiatric symptoms in Alzheimer's disease.PloS one · 2017Article
- Spine Enlargement of Pyramidal Tract-Type Neurons in the Motor Cortex of a Rat Model of Levodopa-Induced Dyskinesia.Frontiers in neuroscience · 2017Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Dystrophic changes in dendrites of cortical neurons are present in several neuro-psychiatric disorders, including schizophrenia. The mechanisms that account for dendritic changes in the prefrontal cortex (PFC) in schizophrenia are unclear. Cognitive deficits in schizophrenia have been linked to compromised cortical dopamine function, and the density of the PFC dopamine innervation is decreased in schizophrenia. We determined if 6-hydroxydopamine lesions of the ventral tegmental area that disrupt the PFC dopamine innervation cause dystrophic changes in cortical neurons. Three weeks post-operatively we observed a marked decrease in basal dendritic length and spine density of layer V pyramidal cells in the prelimbic cortex; no change was seen in neurons of the motor cortex. We then examined rats in which the PFC dopamine innervation was lesioned and 3 weeks later were started on chronic treatment with an atypical (olanzapine) or typical (haloperidol) antipsychotic drug. Olanzapine but not haloperidol reversed lesion-induced changes in PFC pyramidal cell dendrites. These data suggest that dopamine regulates dendritic structure in PFC neurons. Moreover, the findings are consistent with a decrease in cortical dopaminergic tone contributing to the pathological changes in the cortex of schizophrenia, and suggest that the progressive cortical loss in schizophrenia may be slowed or reversed by treatment with atypical antipsychotic drugs.
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