ArticleJournal of theoretical biology2007
A computational model of oxygen delivery by hemoglobin-based oxygen carriers in three-dimensional microvascular networks.
Article in Journal of theoretical biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Pericyte KNature cardiovascular research · 2026Article
- Protein kinase Cδ and pharmacomechanical coupling: Re-envisioning cerebral vascular control.The Journal of physiology · 2026Article
- Electro-metabolic signaling.The Journal of general physiology · 2024Article
- Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro.American journal of physiology. Cell physiology · 2021Review
- Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity.PLoS computational biology · 2020Article
- Numerical investigation of oxygen transport by hemoglobin-based carriers through microvessels.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017Article
- The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue.Microcirculation (New York, N.Y. : 1994) · 2017Article
- The capillary bed offers the largest hemodynamic resistance to the cortical blood supply.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Oxygen transport in a three-dimensional microvascular network incorporated with early tumour growth and preexisting vessel cooption: numerical simulation study.BioMed research international · 2015Article
- Oxygen transport in a cross section of the rat inner medulla: impact of heterogeneous distribution of nephrons and vessels.Mathematical biosciences · 2014Article
- Oxygen transport in the microcirculation and its regulation.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Multiscale imaging and computational modeling of blood flow in the tumor vasculature.Annals of biomedical engineering · 2012Review
- Mapping 3-D functional capillary geometry in rat skeletal muscle in vivo.American journal of physiology. Heart and circulatory physiology · 2012Article
- Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels.Nature medicine · 2011Article
- Theoretical models for coronary vascular biomechanics: progress & challenges.Progress in biophysics and molecular biology · 2011Review
- FEM-based oxygen consumption and cell viability models for avascular pancreatic islets.Theoretical biology & medical modelling · 2009Article
- Targeted O2 delivery by blood substitutes: in vitro arteriolar simulations of first- and second-generation products.Microvascular research · 2008Article
- Theoretical models of microvascular oxygen transport to tissue.Microcirculation (New York, N.Y. : 1994) · 2008Review
- Integrative models of vascular remodeling during tumor growth.Wiley interdisciplinary reviews. Systems biology and medicineReview
- Multiscale models of angiogenesis.IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
A detailed computational model is developed to simulate oxygen transport from a three-dimensional (3D) microvascular network to the surrounding tissue in the presence of hemoglobin-based oxygen carriers. The model accounts for nonlinear O(2) consumption, myoglobin-facilitated diffusion and nonlinear oxyhemoglobin dissociation in the RBCs and plasma. It also includes a detailed description of intravascular resistance to O(2) transport and is capable of incorporating realistic 3D microvascular network geometries. Simulations in this study were performed using a computer-generated microvascular architecture that mimics morphometric parameters for the hamster cheek pouch retractor muscle. Theoretical results are presented next to corresponding experimental data. Phosphorescence quenching microscopy provided PO(2) measurements at the arteriolar and venular ends of capillaries in the hamster retractor muscle before and after isovolemic hemodilution with three different hemodilutents: a non-oxygen-carrying plasma expander and two hemoglobin solutions with different oxygen affinities. Sample results in a microvascular network show an enhancement of diffusive shunting between arterioles, venules and capillaries and a decrease in hemoglobin's effectiveness for tissue oxygenation when its affinity for O(2) is decreased. Model simulations suggest that microvascular network anatomy can affect the optimal hemoglobin affinity for reducing tissue hypoxia. O(2) transport simulations in realistic representations of microvascular networks should provide a theoretical framework for choosing optimal parameter values in the development of hemoglobin-based blood substitutes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.