ArticleGenome biology2007
Reduced selection leads to accelerated gene loss in Shigella.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
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- Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei.Nature communications · 2025Article
- No Genomic Signatures Were Found inVeterinary sciences · 2025Article
- Tracing and characterization of foodborne botulism caused by the new MLST typeFrontiers in microbiology · 2025Article
- Investigating Anthrax-Associated Virulence Genes among Archival and ContemporaryPathogens (Basel, Switzerland) · 2024Article
- Detecting genetic gain and loss events in terms of protein domain: Method and implementation.Heliyon · 2024Article
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- Phylogenomic discernments into Anaerolineaceae thermal adaptations and the proposal of a candidate genusFrontiers in microbiology · 2024Article
- Large genomic deletions delineate Mycobacterium tuberculosis L4 sublineages in South American countries.PloS one · 2023Article
- Genomics and pathotypes of the many faces of Escherichia coli.FEMS microbiology reviews · 2022Article
- The Evolutionary Conservation of Escherichia coli Drug Efflux Pumps Supports Physiological Functions.Journal of bacteriology · 2020Review
- Differential loss of effector genes in three recently expanded pandemic clonal lineages of the rice blast fungus.BMC biology · 2020Article
- Complete genome sequence and annotation of the laboratory reference strain Shigella flexneri serotype 5a M90T and genome-wide transcriptional start site determination.BMC genomics · 2020Article
- Adenine Enrichment at the Fourth CDS Residue in Bacterial Genes Is Consistent with Error Proofing for +1 Frameshifts.Molecular biology and evolution · 2017Article
- Horizontal Acquisition and Transcriptional Integration of Novel Genes in Mosquito-Associated Spiroplasma.Genome biology and evolution · 2017Article
- Extreme mutation bias and high AT content in Plasmodium falciparum.Nucleic acids research · 2017Article
- Winding paths to simplicity: genome evolution in facultative insect symbionts.FEMS microbiology reviews · 2016Review
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3 authors.
Funding
Abstract
backgroundObligate pathogenic bacteria lose more genes relative to facultative pathogens, which, in turn, lose more genes than free-living bacteria. It was suggested that the increased gene loss in obligate pathogens may be due to a reduction in the effectiveness of purifying selection. Less attention has been given to the causes of increased gene loss in facultative pathogens.
resultsWe examined in detail the rate of gene loss in two groups of facultative pathogenic bacteria: pathogenic Escherichia coli, and Shigella. We show that Shigella strains are losing genes at an accelerated rate relative to pathogenic E. coli. We demonstrate that a genome-wide reduction in the effectiveness of selection contributes to the observed increase in the rate of gene loss in Shigella.
conclusionWhen compared with their closely related pathogenic E. coli relatives, the more niche-limited Shigella strains appear to be losing genes at a significantly accelerated rate. A genome-wide reduction in the effectiveness of purifying selection plays a role in creating this observed difference. Our results demonstrate that differences in the effectiveness of selection contribute to differences in rate of gene loss in facultative pathogenic bacteria. We discuss how the lifestyle and pathogenicity of Shigella may alter the effectiveness of selection, thus influencing the rate of gene loss.
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