SynthesisDer Internist2007
[Injuries from needles contaminated with hepatitis C virus: how high is the risk of seroconversion for medical personnel really?].
Synthesis in Der Internist, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- [High-risk needlestick injuries and virus transmission : A prospective observational study].Der Unfallchirurg · 2020Observational
- Hepatitis C virus: Morphogenesis, infection and therapy.World journal of hepatology · 2018Review
- Seroconversion after needlestick injuries - analyses of statutory accident insurance claims in Germany.GMS hygiene and infection control · 2018Article
- Work-related infections in dentistry: risk perception and preventive measures.Clinical oral investigations · 2017Article
- Childhood exposures to discarded needles and other objects potentially contaminated with blood-borne pathogens in Toronto, Canada.Paediatrics & child health · 2017Article
- [Risk estimation of blood-borne infections by emergency room personnel].Der Unfallchirurg · 2016Article
- The Prevalence of Accidental Needle Stick Injury and their Reporting among Healthcare Workers in Orthopaedic Wards in General Hospital Melaka, Malaysia.Malaysian orthopaedic journal · 2014Article
- Best practice for needlestick injuries.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2014Article
- [Early diagnosis of hepatitis C transmission after needlestick injury].Der Unfallchirurg · 2013Article
- [Blood-borne infections and the pregnant health care worker. Risks and preventive measures].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2012Article
- [Prevention of virus hepatitis A to E].Der Internist · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk of infection after injury with a needle contaminated with hepatitis C virus (HCV) is thought to be about 3%, but this assumption is mainly based on studies published in the 1990's, which were limited by small sample sizes and insensitive HCV-RNA assays. We therefore investigated needle injuries at the Hannover Medical School over a period of 6 years and performed a systematic review of the literature identifying 22 studies with a total of 6,956 injuries with HCV contaminated needles. Between 2000 and 2005, 1,431 occupational injuries were reported at our institution and two-thirds were needle injuries. Index patients were known to be HCV infected in 166 cases but there were no cases of HCV seroconversion during follow-up. Analysis of published data showed seroconversion rates of 0-10.3% with a mean of 0.75% (52/6,956). The risk of acute HCV infection was lower in Europe with 0.42% compared to Eastern Asia with 1.5% of cases where an HCV viremia was reported during follow-up. In summary, the risk of acquiring an HCV infection after a needlestick injury is lower than frequently reported. Worldwide differences in HCV seroconversion rates suggest that genetic factors might provide some level of natural resistance against HCV. Future studies should address not only the frequency of acute hepatitis but also factors associated with a higher risk of becoming HCV infected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.