Trial reportEuropean journal of clinical nutrition2008
Effect of vitamin A supplementation on immune function of well-nourished children suffering from vitamin A deficiency in China.
Trial report in European journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 6 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Pooled it
- Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.The Cochrane database of systematic reviews · 2017Pooled it
- The phenomenon of micronutrient deficiency among children in China: a systematic review of the literature.Public health nutrition · 2014Pooled it
- Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2011Pooled it
- Ingestion of micronutrient fortified breakfast cereal has no influence on immune function in healthy children: a randomized controlled trial.Nutrition journal · 2011Trial
- Causality of circulating vitamins on infectious diseases: integrating Mendelian randomization andFrontiers in immunology · 2025Article
- Trends and forecasts of vitamin A deficiency burden in China, 1990-2035.Frontiers in nutrition · 2025Article
- Association Between Serum Vitamin A Levels and Recurrent Respiratory Tract Infections in Children.Frontiers in pediatrics · 2021Article
- Vitamin composition of ethnic foods commonly consumed in Europe.Food & nutrition research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo clearly clarify the protective effect of vitamin A supplementation on immune function of well-nourished children suffering from vitamin A deficiency.
methodsThree hundred sixty-two children in two kindergartens in Wuhan China were enrolled. Detailed dietary assessment and anthropometry were undertaken to facilitate the exclusion of malnourished children. Seventy vitamin A-deficient children with informed consent were randomly divided into the vitamin A-deficient-supplemented group and vitamin A-deficient placebo group, 35 vitamin A-sufficient children (age- and sex-matched with the vitamin A-deficient-supplemented group children) were selected as vitamin A-sufficient placebo group. The baseline and follow-up level of selected immune parameters of the 105 children in three intervention groups were compared.
resultsThe total proportion of severe and marginal vitamin A-deficient children was 10.9 and 21.96%, respectively. At baseline, the serum complement C3 and sIgA level of vitamin A-sufficient children was significantly higher than that of vitamin A-deficient children (P < 0.05). However, the serum lysozyme level of vitamin A-sufficient children was inversely lower. After intervention, vitamin A-deficient-supplemented children increased serum vitamin A, complement C3 and sIgA level, but their serum lysozyme level inversely decreased.
conclusionsVitamin A deficiency was still a serious health problem in children in China cities. Vitamin A supplementation was efficacious in ameliorating serum vitamin A status and partially impaired immune function of well-nourished children suffering from vitamin A deficiency.
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