ArticleProceedings of the National Academy of Sciences of the United States of America2007
Bound attractant at the leading vs. the trailing edge determines chemotactic prowess.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 104 citations in OpenAlex.
- Computational insights on the interplay between electrotaxis and mechanotaxis.PLoS computational biology · 2026Article
- Competing signaling pathways controls electrotaxis.iScience · 2025Article
- Traveling-wave chemotaxis of neutrophil-like HL-60 cells.Molecular biology of the cell · 2025Article
- Decoding physical principles of cell migration under controlled environment using microfluidics.Biophysics reviews · 2024Review
- Engineering physical microenvironments to study innate immune cell biophysics.APL bioengineering · 2022Review
- Simulating CXCR5 Dynamics in Complex Tissue Microenvironments.Frontiers in immunology · 2021Article
- Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation.Scientific reports · 2020Article
- A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration.Nature cell biology · 2020Article
- Adaptation of Living Systems.Annual review of condensed matter physics · 2018Article
- Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay.Molecular biology of the cell · 2017Article
- Determining whether observed eukaryotic cell migration indicates chemotactic responsiveness or random chemokinetic motion.Journal of theoretical biology · 2017Article
- A dual-docking microfluidic cell migration assay (DIntegrative biology : quantitative biosciences from nano to macro · 2017Article
- Temporal gradients limit the accumulation of neutrophils towards sources of chemoattractant.Microsystems & nanoengineering · 2017Article
- Quantitative analysis of B-lymphocyte migration directed by CXCL13.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics.Journal of leukocyte biology · 2016Review
- Gαi2 and Gαi3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Modeling and analysis of collective cell migration in an in vivo three-dimensional environment.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells.PloS one · 2016Article
- Cell-cell signalling in sexual chemotaxis: a basis for gametic differentiation, mating types and sexes.Journal of the Royal Society, Interface · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We have analyzed chemotaxis of neutrophil-differentiated HL60 cells in microfluidic devices that create exponential gradients of the chemoattractant, f-Met-Leu-Phe (fMLP). Such gradients expose each cell to a difference in fMLP concentration (DeltaC) across its diameter that is directly proportional to the ambient concentration (C) at that cell's position in the gradient, so the ratio DeltaC/C is constant everywhere. Cells exposed to ambient fMLP concentrations near the constant of dissociation (K(d)) for fMLP binding to its receptor ( approximately 10 nM) crawl much less frequently when DeltaC/C is 0.05 than when it is 0.09 or 0.13. Hence, cells can detect the gradient across their diameter without moving and, thus, without experiencing temporal changes in attractant concentration. At all DeltaC/C ratios tested, the average chemotactic prowess of individual cells (indicated by the distance a cell traveled in the correct direction divided by the length of its migration path) is maximal for cells that start migrating at concentrations near the K(d) and progressively decreases at higher or lower starting concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.