ArticleInfection and immunity2007
Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signaling.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection.Pathogens (Basel, Switzerland) · 2023Review
- Influence ofFrontiers in immunology · 2021Review
- The Host Autophagy DuringFrontiers in microbiology · 2020Review
- Interplay BetweenFrontiers in cellular and infection microbiology · 2019Review
- The Interplay of Host Autophagy and Eukaryotic Pathogens.Frontiers in cell and developmental biology · 2018Review
- Memory-phenotype CD4Science immunology · 2017Article
- LAP-like process as an immune mechanism downstream of IFN-γ in control of the human malaria Plasmodium vivax liver stage.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The gene expression level of IFN-γR1 and IFN-γR2 in a murine model treated with Toxoplasma gondii and its products.Gastroenterology and hepatology from bed to bench · 2016Article
- Hidden behind autophagy: the unconventional roles of ATG proteins.Traffic (Copenhagen, Denmark) · 2013Review
- Sorafenib induces autophagy and suppresses activation of human macrophage.International immunopharmacology · 2013Article
- Use and abuse of dendritic cells by Toxoplasma gondii.Virulence · 2012Review
- Immune response and immunopathology during toxoplasmosis.Seminars in immunopathology · 2012Review
- Interferon-inducible effector mechanisms in cell-autonomous immunity.Nature reviews. Immunology · 2012Review
- Article
- Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii.Infection and immunity · 2010Article
- CCR7-dependent immunity during acute Toxoplasma gondii infection.Infection and immunity · 2010Article
- Long-term immunity to lethal acute or chronic type II Toxoplasma gondii infection is effectively induced in genetically susceptible C57BL/6 mice by immunization with an attenuated type I vaccine strain.Infection and immunity · 2009Article
- Genetic identification of essential indels and domains in carbamoyl phosphate synthetase II of Toxoplasma gondii.International journal for parasitology · 2009Article
- Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells.The Journal of experimental medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Autophagy has been implicated in the intracellular destruction of Toxoplasma gondii by primed macrophages following gamma interferon (IFN-gamma) activation of p47 GTPases. CD40 ligation has also been shown to trigger autophagic elimination of T. gondii independent of IFN-gamma and p47 GTPases. Here we demonstrate that IFN-gamma/p47 GTPase-dependent elimination of T. gondii by strain CPS vaccine-primed macrophages is independent of CD40/tumor necrosis factor signaling. Similar to wild-type controls, both CD40-deficient and tumor necrosis factor receptor 1/2 (TNFR1/2)-deficient macrophages can efficiently eliminate invaded strain GFP-PTG and restrain its replication following priming. In contrast, macrophages from mice lacking the IFN-gamma receptor gene neither clear the parasites nor repress their proliferation. Thus, CD40 and IFN-gamma-induced pathogen elimination might represent two independent resistance pathways, the latter of which plays a primary role in anti-Toxoplasma immunity in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.