ArticleInfection and immunity2007
Overproduction of DNA adenine methyltransferase alters motility, invasion, and the lipopolysaccharide O-antigen composition of Yersinia enterocolitica.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Epigenetic regulation in prokaryotes: transcriptional and phenotypic outcomes of DNA methyltransferase activity.FEMS microbiology reviews · 2026Review
- Comparison ofEpigenomes · 2023Article
- Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria.Frontiers in microbiology · 2023Review
- The extremophileFrontiers in microbiology · 2023Article
- Integration of themBio · 2022Article
- Review
- The bacterial epigenome.Nature reviews. Microbiology · 2020Review
- Comparative Analysis ofFrontiers in plant science · 2017Article
- DNA Methylation.EcoSal Plus · 2014Article
- The dam replacing gene product enhances Neisseria gonorrhoeae FA1090 viability and biofilm formation.Frontiers in microbiology · 2014Article
- Article
- Inhibition of Yersinia pestis DNA adenine methyltransferase in vitro by a stibonic acid compound: identification of a potential novel class of antimicrobial agents.British journal of pharmacology · 2013Article
- The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes.Nature reviews. Microbiology · 2010Review
- Article
- Dam methylation controls O-antigen chain length in Salmonella enterica serovar enteritidis by regulating the expression of Wzz protein.Journal of bacteriology · 2009Article
- Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.FEMS microbiology reviews · 2009Review
- Role of the Campylobacter jejuni Cj1461 DNA methyltransferase in regulating virulence characteristics.Journal of bacteriology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA adenine methyltransferase (Dam) not only regulates basic cellular functions but also interferes with the proper expression of virulence factors in various pathogens. We showed previously that for the human pathogen Yersinia enterocolitica, overproduction of Dam results in increased invasion of epithelial cells. Since invasion and motility are coordinately regulated in Y. enterocolitica, we analyzed the motility of a Dam-overproducing (Dam(OP)) strain and found it to be highly motile. In Dam(OP) strains, the operon encoding the master regulator of flagellum biosynthesis, flhDC, is upregulated. We show that the increased invasion is not due to enhanced expression of known and putative Y. enterocolitica invasion and adhesion factors, such as Inv, YadA, Ail, Myf fibrils, Pil, or Flp pili. However, overproduction of Dam no longer results in increased invasion for an inv mutant strain, indicating that Inv is necessary for increased invasion after overproduction of Dam. Since we show that overproduction of Dam results in an increased amount of rough lipopolysaccharide (LPS) molecules lacking O-antigen side chains, this implies that reduced steric hindrance by LPS might contribute to increased invasion by a Y. enterocolitica Dam(OP) strain. Our data add an important new aspect to the various virulence-associated phenotypes influenced by DNA methylation in Y. enterocolitica and indicate that Dam targets regulatory processes modulating the composition and function of the bacterial surface.
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