Evidence map›Paper›PMID 17681845›Full record

ReviewCytokine & growth factor reviews

Lost in the world of functional genomics, systems biology, and translational research: is there life after the Milstein award?

Michael G Katze, Marcus J Korth

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cytokine & growth factor reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. SARS-CoV virus-host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin-fixed paraffin-embedded tissues.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2006
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael G KatzeDepartment of Microbiology and Washington National Primate Research Center, University of Washington, Seattle, WA 98195-8070, USA. honey@u.washington.edu
Marcus J Korth

Funding

YILMA SIV VACCINIA VACCINE TRIALP51RR000166 · NCRR · UNIVERSITY OF WASHINGTON · PI HU, SHIU-LOK · 1985 to 2011
$161.1M
Viral and Host cDNA Libraries from 1918 Influenza CasesP01AI058113 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GARCIA-SASTRE, ADOLFO · 2004 to 2010
$20.3M
PROTEOMICS COREP30DA015625 · NIDA · UNIVERSITY OF WASHINGTON · PI KATZE, MICHAEL G · 2002 to 2012
$18.9M
DEVELOPMENT OF A PRIMATE GENOMICS RESOURCER24RR016354 · NCRR · UNIVERSITY OF WASHINGTON · PI KATZE, MICHAEL G · 2002 to 2011
$9.7M
STRUCTURAL BIOLOGY OF HLA-A,B ANTIGENSR01AI017892 · NIAID · STANFORD UNIVERSITY · PI PARHAM, PETER R · 1985 to 2019
$6.1M
Mechanisms for viral evasion of innate immune responseP01AI052106 · NIAID · UNIVERSITY OF WASHINGTON · PI PALESE, PETER · 2002 to 2006
$3.4M
TRANSLATION CONTROL OF INFLUENZA VIRUS INFECTED CELLSR01AI022646 · NIAID · UNIVERSITY OF WASHINGTON · PI KATZE, MICHAEL G · 1986 to 2009
$3.4M
Macaque Model and Gene Expression Profiling of SARSR01HL080621 · NHLBI · UNIVERSITY OF WASHINGTON · PI KATZE, MICHAEL G · 2006 to 2009
$2.5M
HEPATITIS C VIRUS:PATHOGENESIS AND CELLULAR SIGNALINGR01AI047304 · NIAID · UNIVERSITY OF WASHINGTON · PI KATZE, MICHAEL G · 2001 to 2005
$1.6M
Gene Expression Profiling in Filovirus-Infected CellsR21AI063436 · NIAID · UNIVERSITY OF WASHINGTON · PI KATZE, MICHAEL G · 2005 to 2006
$510k
GENE EXPRESSION PROFILING OF AIDS VACCINE STRATEGIESR21AI071892 · NIAID · UNIVERSITY OF WASHINGTON · PI KATZE, MICHAEL G · 2006 to 2007
$491k
NCRR NIH HHS P51 RR000166NCRR NIH HHS P51RR000166NCRR NIH HHS R24 RR016354NCRR NIH HHS R24RR-016354NHLBI NIH HHS R01 HL080621NHLBI NIH HHS R01HL080621NIAID NIH HHS P01 AI052106NIAID NIH HHS P01AI052106NIAID NIH HHS P01 AI058113NIAID NIH HHS P01AI058113NIAID NIH HHS R01 AI017892NIAID NIH HHS R01 AI022646NIAID NIH HHS R01AI022646NIAID NIH HHS R01 AI047304NIAID NIH HHS R21AI017892NIAID NIH HHS R21 AI063436NIAID NIH HHS R21AI063436NIAID NIH HHS R21 AI071892NIDA NIH HHS P30 DA015625NIDA NIH HHS P30DA015625
6 · The paper itself

Abstract

We have always wanted to save the world from the scourges of virus infection by developing better drugs and vaccines. But fully understanding the intricacies of virus-host interactions, the first step in achieving this goal, requires the ability to view the process on a grand scale. The advent of high-throughput technologies, such as DNA microarrays and mass spectrometry, provided the first opportunities to obtain such a view. Here, we describe our efforts to use these tools to focus on the changes in cellular gene expression and protein abundance that occur in response to virus infection. By examining these changes in a comprehensive manner, we have been able to discover exciting new insights into innate immunity, interferon and cytokine signaling, and the strategies used by viruses to overcome these cellular defenses. Functional genomics may yet save the world from killer viruses.

Indexed as

GenomicsAcquired Immunodeficiency SyndromeAnimalsAwards and PrizesComputational BiologyDisease Models, AnimalGene ExpressionHepatitis CHost-Pathogen InteractionsHumansInfluenza, HumanLiverViruses

Identifiers

PMID17681845
PMCPMC1994668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.