ArticleNeuroscience2007
Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function.
Article in Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Potential Neuroprotective Role of Neurotrophin in Traumatic Brain Injury.CNS & neurological disorders drug targets · 2024Review
- The Roles of Neurotrophins in Traumatic Brain Injury.Life (Basel, Switzerland) · 2021Review
- Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome.Journal of neurotrauma · 2018Article
- Expression profile of plasma microRNAs and their roles in diagnosis of mild to severe traumatic brain injury.PloS one · 2018Article
- Hippocampal Neurophysiologic Changes after Mild Traumatic Brain Injury and Potential Neuromodulation Treatment Approaches.Frontiers in systems neuroscience · 2016Review
- Circulating proteasome activity following mild head injury in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Caffeic Acid phenethyl ester protects blood-brain barrier integrity and reduces contusion volume in rodent models of traumatic brain injury.Journal of neurotrauma · 2012Article
- Neurodegeneration in the somatosensory cortex after experimental diffuse brain injury.Brain structure & function · 2012Article
- Peptide-mediated targeting of liposomes to TrkB receptor-expressing cells.International journal of nanomedicine · 2012Article
- Identification of potentially neuroprotective genes upregulated by neurotrophin treatment of CA3 neurons in the injured brain.Journal of neurotrauma · 2011Article
- Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.PloS one · 2011Article
- Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury.Journal of neurotrauma · 2010Article
- Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats.PloS one · 2010Article
- Voluntary exercise may engage proteasome function to benefit the brain after trauma.Brain research · 2010Article
- Analysis of neurotrophins in human serum by immunoaffinity capillary electrophoresis (ICE) following traumatic head injury.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2010Article
- Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury.Neuroscience · 2009Article
- Sulforaphane improves cognitive function administered following traumatic brain injury.Neuroscience letters · 2009Article
- Small molecule activators of the Trk receptors for neuroprotection.BMC neuroscience · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Traumatic brain injury (TBI) causes selective hippocampal cell death which is believed to be associated with the cognitive impairment observed in both clinical and experimental settings. The endogenous neurotrophin-4/5 (NT-4/5), a TrkB ligand, has been shown to be neuroprotective for vulnerable CA3 pyramidal neurons after experimental brain injury. In this study, infusion of recombinant NT-4/5 increased survival of CA2/3 pyramidal neurons to 71% after lateral fluid percussion brain injury in rats, compared with 55% in vehicle-treated controls. The functional outcome of this NT-4/5-mediated neuroprotection was examined using three hippocampal-dependent behavioral tests. Injury-induced impairment was evident in all three tests, but interestingly, there was no treatment-related improvement in any of these measures. Similarly, injury-induced decreased excitability in the Schaffer collaterals was not affected by NT-4/5 treatment. We propose that a deeper understanding of the factors that link neuronal survival to recovery of function will be important for future studies of potentially therapeutic agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.