ArticleBiomaterials2007
Reduced foreign body response at nitric oxide-releasing subcutaneous implants.
Article in Biomaterials, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 155 citations in OpenAlex.
- Smartphone-Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- In Situ Nitric Oxide Generating Nano-Bioactive Glass-Based Coatings and Its Therapeutic Ion Release toward Attenuating Implant-Associated Fibrosis and Infection.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Implantable Passive Sensors for Biomedical Applications.Sensors (Basel, Switzerland) · 2024Review
- Foreign Body Reaction to Ion-Beam-Treated Polyurethane Implant.Materials (Basel, Switzerland) · 2024Article
- Engineered collagen polymeric materials create noninflammatory regenerative microenvironments that avoid classical foreign body responses.Biomaterials science · 2023Article
- Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy.Pharmacological reviews · 2022Review
- Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release.International journal of molecular sciences · 2022Article
- Prevention of medical device infections via multi-action nitric oxide and chlorhexidine diacetate releasing medical grade silicone biointerfaces.Journal of biomedical materials research. Part A · 2022Article
- Electrospun Bioabsorbable Fibers ContainingACS applied bio materials · 2020Article
- Mimicking the Endothelium: Dual Action Heparinized Nitric Oxide Releasing Surface.ACS applied materials & interfaces · 2020Article
- Versatile biomimetic medical device surface: hydrophobin coated, nitric oxide-releasing polymer for antimicrobial and hemocompatible applications.Biomaterials science · 2019Article
- Biocompatibility of common implantable sensor materials in a tumor xenograft model.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Nitric oxide releasing poly(vinylidene fluoride-co-hexafluoropropylene) films using a fluorinated nitric oxide donor to greatly decrease chemical leaching.Acta biomaterialia · 2019Article
- Biomaterials: Foreign Bodies or Tuners for the Immune Response?International journal of molecular sciences · 2019Review
- Nitric oxide-releasing semi-crystalline thermoplastic polymers: preparation, characterization and application to devise anti-inflammatory and bactericidal implants.Biomaterials science · 2018Article
- Synthesis and Characterization of a FluorinatedJournal of materials chemistry. B · 2018Article
- Microfluidics-Enabled Multimaterial Maskless Stereolithographic Bioprinting.Advanced materials (Deerfield Beach, Fla.) · 2018Article
- Influence of diabetes on the foreign body response to nitric oxide-releasing implants.Biomaterials · 2018Article
- Nitric Oxide Release for Improving Performance of Implantable Chemical Sensors - A Review.Applied materials today · 2017Article
- Compatibility of Nitric Oxide Release with Implantable Enzymatic Glucose Sensors Based on Osmium (III/II) Mediated Electrochemistry.ACS sensors · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The tissue response to nitric oxide (NO)-releasing subcutaneous implants is presented. Model implants were created by coating silicone elastomer with diazeniumdiolate-modified xerogel polymers capable of releasing NO. The host tissue response to such implants was evaluated at 1, 3, and 6 weeks and compared to that of uncoated silicone elastomer blanks and xerogel-coated controls incapable of releasing NO. Delivery of NO (approximately 1.35 micromol/cm2 of implant surface area) reduced foreign body collagen capsule ("scar tissue") thickness by >50% compared to uncoated silicone elastomer after 3 weeks. The chronic inflammatory response at the tissue/implant interface was also reduced by >30% at NO-releasing implants after 3 and 6 weeks. Additionally, CD-31 immunohistochemical staining revealed approximately 77% more blood vessels in proximity to NO-releasing implants after 1 week compared to controls. These findings suggest that conferring NO release to subcutaneous implants may promote effective device integration into healthy vascularized tissue, diminish foreign body capsule formation, and improve the performance of indwelling medical devices that require constant mass transport of analytes (e.g., implantable sensors).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.