ArticleInsect biochemistry and molecular biology2007
Post-integration stability of piggyBac in Aedes aegypti.
Article in Insect biochemistry and molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Unpredictable recombination of PB transposon in Silkworm: a potential risk.Molecular genetics and genomics : MGG · 2021Article
- Review
- Molecular tools to create new strains for mosquito sexing and vector control.Parasites & vectors · 2018Review
- Modern Vector Control.Cold Spring Harbor perspectives in medicine · 2018Review
- Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?International journal of environmental research and public health · 2017Review
- nanos-Driven expression of piggyBac transposase induces mobilization of a synthetic autonomous transposon in the malaria vector mosquito, Anopheles stephensi.Insect biochemistry and molecular biology · 2017Article
- Article
- Control of Mosquito-Borne Infectious Diseases: Sex and Gene Drive.Trends in parasitology · 2016Review
- Tools for Anopheles gambiae Transgenesis.G3 (Bethesda, Md.) · 2015Article
- Atypical mitogen-activated protein kinase phosphatase implicated in regulating transition from pre-S-Phase asexual intraerythrocytic development of Plasmodium falciparum.Eukaryotic cell · 2013Article
- Article
- Article
- Gal4-based enhancer-trapping in the malaria mosquito Anopheles stephensi.G3 (Bethesda, Md.) · 2012Article
- ATon, abundant novel nonautonomous mobile genetic elements in yellow fever mosquito (Aedes aegypti).BMC genomics · 2012Article
- New Insights into Control of Arbovirus Replication and Spread by Insect RNA Interference Pathways.Insects · 2012Review
- The mosquito Aedes aegypti has a large genome size and high transposable element load but contains a low proportion of transposon-specific piRNAs.BMC genomics · 2011Article
- piggyBac transposon remobilization and enhancer detection in Anopheles mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Size matters: versatile use of PiggyBac transposons as a genetic manipulation tool.Molecular and cellular biochemistry · 2011Review
- Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites.BMC genomics · 2011Article
- A new powerful method for site-specific transgene stabilization based on chromosomal double-strand break repair.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The post-integration activity of piggyBac transposable element gene vectors in Aedes aegypti mosquitoes was tested under a variety of conditions. The embryos from five independent transgenic lines of Ae. aegypti, each with a single integrated non-autonomous piggyBac transposable element gene vector, were injected with plasmids containing the piggyBac transposase open-reading frame under the regulatory control of the Drosophila melanogaster hsp70 promoter. No evidence for somatic remobilization was detected in the subsequent adults whereas somatic remobilization was readily detected when similar lines of transgenic D. melanogaster were injected with the same piggyBac transposase-expressing plasmid. Ae. aegypti heterozygotes of piggyBac reporter-containing transgenes and piggyBac transposase-expressing transgenes showed no evidence of somatic and germ-line remobilization based on phenotypic and molecular detection methods. The post-integration mobility properties of piggyBac in Ae. aegypti enhance the utility of this gene vector for certain applications, particularly those where any level of vector remobilization is unacceptable.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.