ArticleSarcoma2007
The influence of elementary silver versus titanium on osteoblasts behaviour in vitro using human osteosarcoma cell lines.
Article in Sarcoma, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Antimicrobial Materials Used in Coating Dental Implant Surfaces: State of the Art and Future Prospectives.Materials (Basel, Switzerland) · 2026Review
- Human T-Cell Responses to Metallic Ion-Doped Bioactive Glasses.International journal of molecular sciences · 2024Article
- Silver-integrated EDM processing of TiAl6V4 implant material has antibacterial capacity while optimizing osseointegration.Bioactive materials · 2024Article
- In Vitro and In Vivo Studies of Antibacterial Coatings on Titanium Alloy Implants for Veterinary Application.International journal of molecular sciences · 2023Article
- Case Series of Silver Oxide-Containing Hydroxyapatite Coating in Antibacterial Cementless Total Hip Arthroplasty: Clinical Results of 50 Cases at 5-Year Follow-Up.Arthroplasty today · 2023Article
- Antibacterial Adhesion Strategy for Dental Titanium Implant Surfaces: From Mechanisms to Application.Journal of functional biomaterials · 2022Review
- Development of Silver-Containing Hydroxyapatite-Coated Antimicrobial Implants for Orthopaedic and Spinal Surgery.Medicina (Kaunas, Lithuania) · 2022Review
- Antibacterial metals and alloys for potential biomedical implants.Bioactive materials · 2021Review
- Biocompatible Nanocomposite Implant with Silver Nanoparticles for Otology-In Vivo Evaluation.Nanomaterials (Basel, Switzerland) · 2018Article
- Silver-coated megaprostheses: review of the literature.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2017Review
- Influence of the Microstructure and Silver Content on Degradation, Cytocompatibility, and Antibacterial Properties of Magnesium-Silver Alloys In Vitro.Oxidative medicine and cellular longevity · 2017Article
- Evaluation of osseous integration of PVD-silver-coated hip prostheses in a canine model.BioMed research international · 2015Article
- Densification, phase stability and in vitro biocompatibility property of hydroxyapatite-10 wt% silver composites.Journal of materials science. Materials in medicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose. The antimicrobial effect of a silver-coated tumor endoprosthesis has been proven in clinical and experimental trials. However, in the literature there are no reports concerning the effect of elementary silver on osteoblast behaviour. Therefore, the prosthetic stem was not silver-coated because of concerns regarding a possible inhibition of the osseointegration. The aim of the present study was to investigate the effect of 5-25 mg of elementary silver in comparison to Ti-6Al-4V on human osteosarcoma cell lines (HOS-58, SAOS). Methods. Cell viability was determined by measuring the MTT proliferation rate. Cell function was studied by measuring alkaline phosphatase (AP) activity and osteocalcine production. Results. In the HOS-58 cells, the AP activity was statistically significant (P < 0.05) higher at a supplement of 5-10 mg of silver than of Ti-6 Al-4V at the same doses. For both cell lines, a supplement above 10 mg of silver resulted in a reduced AP activity in comparision to the Ti-6 Al-4V group, but a statistically significant difference (P < 0.05) was observed at a dose of 25 mg for the SAOS cells only. At doses of 20-25 mg in the HOS-58 cells and 10-25 mg in the SAOS cells, the reduction of the proliferation rate by silver was statistically significant (P < 0.05) compared to the Ti-6 Al-4V supplement. Discussion. In conclusion, elementary silver exhibits no cytotoxicity at low concentrations. In contrast, it seems to be superior to Ti-6 Al-4V concerning the stimulation of osteogenic maturation at these concentrations, whereas at higher doses it causes the known cytotoxic properties.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.