ArticleProceedings of the National Academy of Sciences of the United States of America2007
Immune complex-induced enhancement of bacterial antigen presentation requires Fcgamma receptor III expression on dendritic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Engineering therapeutic monoclonal antibodies.The Journal of allergy and clinical immunology · 2024Review
- Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses.Virulence · 2020Article
- Article
- Non-Specific Antibodies Induce Lysosomal Activation in Atlantic Salmon Macrophages Infected byFrontiers in immunology · 2020Article
- The Complex Association of FcγRIIb With Autoimmune Susceptibility.Frontiers in immunology · 2019Review
- Beyond binding: antibody effector functions in infectious diseases.Nature reviews. Immunology · 2018Review
- DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.The Journal of experimental medicine · 2017Article
- Recombinant immune complexes as versatile and potent vaccines.Human vaccines & immunotherapeutics · 2016Article
- Contribution of Fcγ receptors to human respiratory syncytial virus pathogenesis and the impairment of T-cell activation by dendritic cells.Immunology · 2016Article
- The Role of FcRn in Antigen Presentation.Frontiers in immunology · 2014Review
- Cross-presentation of IgG-containing immune complexes.Cellular and molecular life sciences : CMLS · 2013Review
- Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity.Immunology · 2012Review
- IgG keeps virulent Salmonella from evading dendritic cell uptake.Immunology · 2012Article
- Intravenous immunoglobulin in the management of lupus nephritis.Autoimmune diseases · 2012Article
- Article
- Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells.Immunology · 2010Article
- Article
- Modulation of nuclear factor-kappaB activity can influence the susceptibility to systemic lupus erythematosus.Immunology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) are capable of initiating adaptive immune responses against infectious agents by presenting pathogen-derived antigens on MHC molecules to naïve T cells. Because of their key role in priming adaptive immunity, it is expected that interfering with DC function would be advantageous to the pathogen. We have previously shown that Salmonella enterica serovar Typhimurium (ST), is able to survive inside DCs and interfere with their function by avoiding activation of bacteria-specific T cells. In contrast, when ST is targeted to Fcgamma receptors on the DC surface, bacteria are degraded and their antigens presented to T cells. However, the specific Fcgamma receptor responsible of restoring presentation of antigens remains unknown. Here, we show that IgG-coated ST was targeted to lysosomes and degraded and its antigens presented on MHC molecules only when the low-affinity activating FcgammaRIII was expressed on DCs. FcgammaRIII-mediated enhancement of Ag presentation led to a robust activation of T cells specific for bacteria-expressed antigens. Laser confocal and electron microscopy analyses revealed that IgG-coated ST was rerouted to the lysosomal pathway through an FcgammaRIII-dependent mechanism. PI-3K activity was required for this process, because specific inhibitors promoted the survival of IgG-coated ST inside DCs and prevented DCs from activating bacteria-specific T cells. Our data suggest that the DC capacity to efficiently activate T cells upon capturing IgG-coated virulent bacteria is mediated by FcgammaRIII and requires PI-3K activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.