Trial reportArchives of general psychiatry2007
Preventing depression in age-related macular degeneration.
Trial report in Archives of general psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00042211 (Preventing Depression in Macular Degeneration), which is not on this map. Cited by 62 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventing Depression in Macular Degeneration
Who cites it
62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Self-management interventions for quality of life in adults with visual impairment.The Cochrane database of systematic reviews · 2025Pooled it
- Pooled it
- Prevention of depression in adults with long-term physical conditions.The Cochrane database of systematic reviews · 2021Pooled it
- Low vision rehabilitation for better quality of life in visually impaired adults.The Cochrane database of systematic reviews · 2020Pooled it
- Preventing the onset of major depressive disorder: a meta-analytic review of psychological interventions.International journal of epidemiology · 2014Pooled it
- Effects of Vitamin DThe Journal of clinical psychiatry · 2023Trial
- Depression Agency-Based Collaborative: Effect of Problem-Solving Therapy on Risk of Common Mental Disorders in Older Adults With Home Care Needs.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Trial
- Effect of a Lay Counselor Intervention on Prevention of Major Depression in Older Adults Living in Low- and Middle-Income Countries: A Randomized Clinical Trial.JAMA psychiatry · 2019Trial
- Measuring Participant Effort in a Depression Prevention Trial: Who Engages in Problem-Solving Therapy?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Trial
- Efficacy of a Maternal Depression Prevention Strategy in Head Start: A Randomized Clinical Trial.JAMA psychiatry · 2017Trial
- Design and Implementation of an Intervention Development Study: Retaining Cognition While Avoiding Late-Life Depression (ReCALL).The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Trial
- Design and Recruitment for a Randomized Controlled Trial of Problem-Solving Therapy to Prevent Depression among Older Adults with Need for Supportive Services.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Trial
- The macular degeneration and aging study: Design and research protocol of a randomized trial for a psychosocial intervention with macular degeneration patients.Contemporary clinical trials · 2015Trial
- Using problem solving therapy to treat veterans with subsyndromal depression: a pilot study.International journal of geriatric psychiatry · 2014Trial
- Low vision depression prevention trial in age-related macular degeneration: a randomized clinical trial.Ophthalmology · 2014Trial
- Early intervention to preempt major depression among older black and white adults.Psychiatric services (Washington, D.C.) · 2014Trial
- Coaching in healthy dietary practices in at-risk older adults: a case of indicated depression prevention.The American journal of psychiatry · 2014Trial
- Improving function in age-related macular degeneration: a randomized clinical trial.Ophthalmology · 2013Trial
- Trial
- Preventing the onset of major depression based on the level and profile of risk of primary care attendees: protocol of a cluster randomised trial (the predictD-CCRT study).BMC psychiatry · 2013Trial
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
contextAge-related macular degeneration is a prevalent disease of aging that may cause irreversible vision loss, disability, and depression. The latter is rarely recognized or treated in ophthalmologic settings.
objectiveTo determine whether problem-solving treatment can prevent depressive disorders in patients with recent vision loss.
designRandomized, controlled trial.
settingOutpatient ophthalmology offices in Philadelphia, Pennsylvania. PATIENTS: Two hundred six patients aged 65 years or older with recent diagnoses of neovascular age-related macular degeneration in one eye and pre-existing age-related macular degeneration in the fellow eye.
interventionPatients were randomly assigned to problem-solving treatment (n = 105) or usual care (n = 101). Problem-solving treatment therapists delivered 6 sessions during 8 weeks in subjects' homes.
main outcome measuresOutcomes were assessed at 2 months for short-term effects and 6 months for maintenance effects. These included DSM-IV-defined diagnoses of depressive disorders, National Eye Institute Vision Function Questionnaire-17 scores, and rates of relinquishing valued activities.
resultsThe 2-month incidence rate of depressive disorders in problem-solving-treated subjects was significantly lower than controls (11.6% vs 23.2%, respectively; odds ratio, 0.39; 95% confidence interval, 0.17-0.92; P = .03). Problem-solving treatment also reduced the odds of relinquishing a valued activity (odds ratio, 0.48; 95% confidence interval, 0.25-0.96; P = .04). This effect mediated the relationship between treatment group and depression. By 6 months, most earlier observed benefits had diminished, though problem-solving treatment subjects were less likely to suffer persistent depression (chi2(1,3) = 8.46; P = .04).
conclusionsProblem-solving treatment prevented depressive disorders and loss of valued activities in patients with age-related macular degeneration as a short-term treatment, but these benefits were not maintained over time. Booster or rescue treatments may be necessary to sustain problem-solving treatment's preventative effect. This study adds important new information to the emerging field of enhanced-care models to prevent or treat depression in older persons.
trial registrationclinicaltrials.gov Identifier: NCT00042211.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.