ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2007
Underestimation of extent of ischemia by gated SPECT myocardial perfusion imaging in patients with left main coronary artery disease.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 1 of them a synthesis that pooled it.
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Who cites it
173 citing papers in PubMed, 1 synthesis or guideline pooled it, 359 citations in OpenAlex.
- Diagnostic Performance of CMR, SPECT, and PET Imaging for the Identification of Coronary Artery Disease: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Improved assessment of coronary artery disease in obese patients with flurpiridaz-Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026Trial
- Predictors of Left Main Coronary Artery Disease in the ISCHEMIA Trial.Journal of the American College of Cardiology · 2022Trial
- Adenoviral intramyocardial VEGF-DΔNΔC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up.European heart journal · 2017Trial
- Trial
- Trial
- Validation of an automated method to quantify stress-induced ischemia and infarction in rest-stress myocardial perfusion SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- Quantification of Myocardial Perfusion Reserve Using Dynamic SPECT Imaging in Humans: A Feasibility Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Trial
- Trial
- Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study.Journal of cardiovascular computed tomographyTrial
- The prognostic value of quantitative myocardial blood flow and flow reserve by dynamic CZT-SPECT for major adverse cardiovascular events.European journal of nuclear medicine and molecular imaging · 2026Article
- Clinical Applications of Artificial Intelligence in Cardiovascular Imaging: Where Do We Stand?Life (Basel, Switzerland) · 2026Review
- Virtual myocardial blood flow and flow reserve from static PET imaging using artificial intelligence.medRxiv : the preprint server for health sciences · 2026Article
- Prognostic significance of non-perfusion parameters of cadmium-zinc-telluride single-photon emission computed tomography myocardial perfusion imaging for individuals with normal myocardial perfusion: a large-scale single-center retrospective cohort study.Annals of nuclear medicine · 2025Article
- Left main coronary artery stenosis presenting with negative myocardial perfusion imaging: a case report of balanced ischaemia.European heart journal. Case reports · 2025Article
- Comparative evaluation of a novel [European journal of nuclear medicine and molecular imaging · 2025Article
- Emerging Applications of Positron Emission Tomography in Coronary Artery Disease.Journal of personalized medicine · 2025Review
- Imaging approaches in risk stratification of patients with coronary artery disease: a narrative review.Archives of medical science : AMS · 2025Article
- Evaluation of the Usefulness of the Myocardial Flow Reserve Index Using an Anger-Type SPECT/CT System.Annals of nuclear cardiology · 2025Article
- Article
113 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere have been limited data regarding the value of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) for the detection of left main coronary artery disease (CAD). METHODS AND
resultsWe studied 101 patients with angiographic left main CAD (> or = 50% stenosis) and no prior myocardial infarction or coronary revascularization who underwent gated exercise or adenosine stress technetium 99m sestamibi SPECT MPI. By perfusion assessment alone, high-risk disease with moderate to severe defects (> 10% myocardium at stress) was identified in only 56% of patients visually and 59% quantitatively. Absence of significant perfusion defect (> or = 5% myocardium) was seen in 13% of patients visually and 15% quantitatively. However, by combining visual perfusion data and nonperfusion variables, especially transient ischemic dilation, 83% of patients were identified as high risk.
conclusionsThe findings of this study demonstrate that assessment of perfusion data alone by visual or quantitative SPECT MPI analysis underestimates the magnitude of left main CAD. The combination of perfusion and nonperfusion abnormalities on gated MPI identifies high risk in most patients with left main CAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.