ArticleBMC evolutionary biology2007
Molecular evolution of the MAGUK family in metazoan genomes.
Article in BMC evolutionary biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 74 citations in OpenAlex.
- Vector semantics of multidomain protein architectures.Bioinformatics advances · 2026Article
- A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- MAGI1 attenuates osteoarthritis by regulating osteoclast fusion in subchondral bone through the RhoA-ROCK1 signaling pathway.Journal of orthopaedic translation · 2025Article
- Genetic evidence for splicing-dependent structural and functional plasticity in CASK protein.Journal of medical genetics · 2024Article
- Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs.Science advances · 2023Article
- Cell polarity signalling at the birth of multicellularity: What can we learn from the first animals.Frontiers in cell and developmental biology · 2022Review
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- Co-expression of synaptic genes in the sponge Amphimedon queenslandica uncovers ancient neural submodules.Scientific reports · 2019Article
- The polarity protein Dlg5 regulates collective cell migration during Drosophila oogenesis.PloS one · 2019Article
- Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca(2+) Channels.Scientific reports · 2016Article
- Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling.Nature reviews. Neuroscience · 2016Review
- Involvement of membrane skeletal molecules in the Schmidt-Lanterman incisure in Schwann cells.Medical molecular morphology · 2016Review
- Evolution of an ancient protein function involved in organized multicellularity in animals.eLife · 2016Article
- Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine.Histochemistry and cell biology · 2016Article
- MPP1 as a Factor Regulating Phase Separation in Giant Plasma Membrane-Derived Vesicles.Biophysical journal · 2015Article
- Mechanistic insight into the functional transition of the enzyme guanylate kinase induced by a single mutation.Scientific reports · 2015Article
- Event inference in multidomain families with phylogenetic reconciliation.BMC bioinformatics · 2015Article
- DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret expression, and apoptosis.Developmental biology · 2014Article
- DLG5 in cell polarity maintenance and cancer development.International journal of biological sciences · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDevelopment, differentiation and physiology of metazoans all depend on cell to cell communication and subsequent intracellular signal transduction. Often, these processes are orchestrated via sites of specialized cell-cell contact and involve receptors, adhesion molecules and scaffolding proteins. Several of these scaffolding proteins important for synaptic and cellular junctions belong to the large family of membrane-associated guanylate kinases (MAGUK). In order to elucidate the origin and the evolutionary history of the MAGUKs we investigated full-length cDNA, EST and genomic sequences of species in major phyla.
resultsOur results indicate that at least four of the seven MAGUK subfamilies were present in early metazoan lineages, such as Porifera. We employed domain sequence and structure based methods to infer a model for the evolutionary history of the MAGUKs. Notably, the phylogenetic trees for the guanylate kinase (GK)-, the PDZ- and the SH3-domains all suggested a matching evolutionary model which was further supported by molecular modeling of the 3D structures of different GK domains. We found no MAGUK in plants, fungi or other unicellular organisms, which suggests that the MAGUK core structure originated early in metazoan history.
conclusionIn summary, we have characterized here the molecular and structural evolution of the large MAGUK family. Using the MAGUKs as an example, our results show that it is possible to derive a highly supported evolutionary model for important multidomain families by analyzing encoded protein domains. It further suggests that larger superfamilies encoded in the different genomes can be analyzed in a similar manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.