ReviewAntioxidants & redox signaling2007
Use of electron paramagnetic resonance spectroscopy to evaluate the redox state in vivo.
Review in Antioxidants & redox signaling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Role of Reactive Oxygen Species in Collagen-Induced Platelet Activation and the Protective Effects of Antioxidants.Antioxidants (Basel, Switzerland) · 2025Article
- Site-Directed Spin Labeling EPR Spectroscopy for Determination of Albumin Structural Damage and Hypoalbuminemia in Critical COVID-19.Antioxidants (Basel, Switzerland) · 2022Article
- Synthesis and characterization of a Cu(ii) coordination-containing TAM radical as a nitroxyl probe.RSC advances · 2022Article
- Quantum Sensing of Free Radicals in Primary Human Dendritic Cells.Nano letters · 2022Article
- A Review of Low-Frequency EPR Technology for the Measurement of Brain pO2 and Oxidative Stress.Applied magnetic resonance · 2021Article
- The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer.International journal of molecular sciences · 2021Article
- Tabletop 700 MHz electron paramagnetic resonance imaging spectrometer.Concepts in magnetic resonance. Part B, Magnetic resonance engineering · 2018Article
- Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment.Analytical chemistry · 2017Review
- Feasibility of magnetic resonance redox imaging at low magnetic field: comparison at 1 T and 7 T.American journal of translational research · 2017Article
- Using Stable Free Radicals to Obtain Unique and Clinically Useful Data In Vivo in Human Subjects.Radiation protection dosimetry · 2016Review
- Muscle damage, metabolism, and oxidative stress in mdx mice: Impact of aerobic running.Muscle & nerve · 2016Article
- In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury.International journal of molecular medicine · 2016Article
- Senescence, Stress, and Reactive Oxygen Species.Plants (Basel, Switzerland) · 2015Review
- Article
- Compressed sensing of spatial electron paramagnetic resonance imaging.Magnetic resonance in medicine · 2014Article
- Selenocysteine confers resistance to inactivation by oxidation in thioredoxin reductase: comparison of selenium and sulfur enzymes.Biochemistry · 2013Article
- Methods for assessing mitochondrial function in diabetes.Diabetes · 2013Review
- Unique oxidation of imidazolidine nitroxides by potassium ferricyanide: strategy for designing paramagnetic probes with enhanced sensitivity to oxidative stress.Free radical research · 2012Article
- Organ specific mapping of in vivo redox state in control and cigarette smoke-exposed mice using EPR/NMR co-imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2012Article
- TRP channels: sensors and transducers of gasotransmitter signals.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The aim of this article is to provide an overview of how electron paramagnetic resonance (EPR) can be used to measure redox-related parameters in vivo. The values of this approach include that the measurements are made under fully physiological conditions, and some of the measurements cannot be made by other means. Three complementary approaches are used with in vivo EPR: the rate of reduction or reactions of nitroxides, spin trapping of free radicals, and measurements of thiols. All three approaches already have produced unique and useful information. The measurement of the rate of decrease of nitroxides technically is the simplest, but difficult to interpret because the measured parameter, reduction in the intensity of the nitroxide signal, can occur by several different mechanisms. In vivo spin trapping can provide direct evidence for the occurrence of specific free radicals in vivo and reflect relative changes, but accurate absolute quantification remains challenging. The measurement of thiols in vivo also appears likely to be useful, but its development as an in vivo technique is at an early stage. It seems likely that the use of in vivo EPR to measure redox processes will become an increasingly utilized and valuable tool.
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Registered trials
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