ReviewPLoS genetics2007
Genetic determinants of human health span and life span: progress and new opportunities.
Review in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed.
- Seven knowledge gaps in modern biogerontology.Biogerontology · 2024Article
- Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants.Epigenetics · 2023Article
- Why twin studies are important for health span science research: the case of maltreatment of aging adults.BMC geriatrics · 2022Review
- Measuring biological age using omics data.Nature reviews. Genetics · 2022Review
- Inside out: Relations between the microbiome, nutrition, and eye health.Experimental eye research · 2022Review
- Protective Effects of Familial Longevity Decrease With Age and Become Negligible for Centenarians.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Ossification timeline of sesamoid bones at metatarsophalangeal joints.Anatomical science international · 2021Article
- Healthspan pathway maps inAging · 2020Review
- Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms.Frontiers in genetics · 2019Article
- Biogerontology: research status, challenges and opportunities.Acta bio-medica : Atenei Parmensis · 2018Review
- Genetic interplay between human longevity and metabolic pathways - a large-scale eQTL study.Aging cell · 2017Article
- Age-associated vulval integrity is an important marker of nematode healthspan.Age (Dordrecht, Netherlands) · 2016Article
- Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.Biogerontology · 2016Article
- Review
- How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Biogerontology · 2016Review
- The Economic Promise of Delayed Aging.Cold Spring Harbor perspectives in medicine · 2015Review
- Asynchrony of senescence among phenotypic traits in a wild mammal population.Experimental gerontology · 2015Article
- Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.Rejuvenation research · 2015Article
- Less functional variants of TLR-1/-6/-10 genes are associated with age.Immunity & ageing : I & A · 2015Article
- Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.Nature communications · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We review three approaches to the genetic analysis of the biology and pathobiology of human aging. The first and so far the best-developed is the search for the biochemical genetic basis of varying susceptibilities to major geriatric disorders. These include a range of progeroid syndromes. Collectively, they tell us much about the genetics of health span. Given that the major risk factor for virtually all geriatric disorders is biological aging, they may also serve as markers for the study of intrinsic biological aging. The second approach seeks to identify allelic contributions to exceptionally long life spans. While linkage to a locus on Chromosome 4 has not been confirmed, association studies have revealed a number of significant polymorphisms that impact upon late-life diseases and life span. The third approach remains theoretical. It would require longitudinal studies of large numbers of middle-aged sib-pairs who are extremely discordant or concordant for their rates of decline in various physiological functions. We can conclude that there are great opportunities for research on the genetics of human aging, particularly given the huge fund of information on human biology and pathobiology, and the rapidly developing knowledge of the human genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.