ArticleThe American journal of pathology2007
Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01407471 (Interest of Topical Spironolactone's Administration to Prevent Corticoid-induced Epidermal Atrophy), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interest of Topical Spironolactone's Administration to Prevent Corticoid-induced Epidermal Atrophy
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Risk factors for androgenetic alopecia: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin.The Journal of investigative dermatology · 2015Trial
- Article
- Article
- The role of the mineralocorticoid receptor in skin.Molecular and cellular endocrinology · 2025Review
- A Systematic Review of Spironolactone Nano-Formulations for Topical Treatment of Skin Hyperandrogenic Disorders and Chronic Wounds.Pharmaceutics · 2024Review
- The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid-induced impaired wound healing.British journal of pharmacology · 2022Article
- Article
- Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment.Scientific reports · 2022Article
- The significance of CYP11A1 expression in skin physiology and pathology.Molecular and cellular endocrinology · 2021Article
- Glucocorticoid-Induced Skin Atrophy: The Old and the New.Clinical, cosmetic and investigational dermatology · 2020Review
- New Insights on the Role of Sodium in the Physiological Regulation of Blood Pressure and Development of Hypertension.Frontiers in cardiovascular medicine · 2019Article
- Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology.International journal of molecular sciences · 2018Review
- Severity of Alopecia Predicts Coronary Changes and Arterial Stiffness in Untreated Hypertensive Men.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- GRowing an epidermal tumor.The Journal of investigative dermatology · 2013Article
- The size of a melanin-based plumage ornament correlates with glucocorticoid receptor concentrations in the skin of that ornament.Biology letters · 2013Article
- Intracellular glucocorticoid receptors in spleen, but not skin, vary seasonally in wild house sparrows (Passer domesticus).Proceedings. Biological sciences · 2013Article
- Could mineralocorticoids play a role in the pathophysiology of open angle glaucoma?Journal of ophthalmology · 2012Article
- Glucocorticoid receptors, epidermal homeostasis and hair follicle differentiation.Dermato-endocrinology · 2011Article
- The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.Nuclear receptor signaling · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mineralocorticoid receptor (MR) is a transcription factor of the nuclear receptor family, activation of which by aldosterone enhances salt reabsorption in the kidney. The MR is also expressed in nonclassical aldosterone target cells (brain, heart, and skin), in which its functions are incompletely understood. To explore the functional importance of MR in mammalian skin, we have generated a conditional doxycycline-inducible model of MR overexpression, resulting in double-transgenic (DT) mice [keratin 5-tTa/tetO-human MR (hMR)], targeting the human MR specifically to keratinocytes of the epidermis and hair follicle (HF). Expression of hMR throughout gestation resulted in early postnatal death that could be prevented by antagonizing MR signaling. DT mice exhibited premature epidermal barrier formation at embryonic day 16.5, reduced HF density and epidermal atrophy, increased keratinocyte apoptosis at embryonic day 18.5, and premature eye opening. When hMR expression was initiated after birth to overcome mortality, DT mice developed progressive alopecia and HF cysts, starting 4 months after hMR induction, preceded by dystrophy and cycling abnormalities of pelage HF. In contrast, interfollicular epidermis, vibrissae, and footpad sweat glands in DT mice were normal. This new mouse model reveals novel biological roles of MR signaling and offers an instructive tool for dissecting nonclassical functions of MR signaling in epidermal, hair follicle, and ocular physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.