ArticleThe American journal of pathology2007
Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and α-Synuclein, as Reported in ALS-PDC.Journal of neuropathology and experimental neurology · 2021Article
- Gut Mucosal Proteins and Bacteriome Are Shaped by the Saturation Index of Dietary Lipids.Nutrients · 2019Article
- Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach.Brain : a journal of neurology · 2018Article
- An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias.Molecular brain · 2017Article
- Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.Molecular genetics and metabolism · 2015Article
- Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.Journal of neuropathology and experimental neurology · 2015Article
- Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease.Experimental and molecular pathology · 2013Article
- Quantitative proteomics for identifying biomarkers for tuberculous meningitis.Clinical proteomics · 2012Article
- Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease.Journal of neurochemistry · 2011Article
- Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?International journal of environmental research and public health · 2011Review
- Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease.Journal of neuropathology and experimental neurology · 2010Article
- Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow.The American journal of pathology · 2010Article
- Quantitation and mapping of cerebral detergent-insoluble proteins in the elderly.Brain pathology (Zurich, Switzerland) · 2009Article
- Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients.Brain pathology (Zurich, Switzerland) · 2009Article
- Different patterns of cerebral injury in dementia with or without diabetes.Archives of neurology · 2009Article
- Application of mass spectrometry-based proteomics for biomarker discovery in neurological disorders.Annals of Indian Academy of Neurology · 2009Article
- Proteomic identification of proteins in the human brain: Towards a more comprehensive understanding of neurodegenerative disease.Proteomics. Clinical applications · 2008Article
- Proteomics of human neurodegenerative diseases.Journal of neuropathology and experimental neurology · 2008Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Parkinsonism-dementia complex (PDC) remains a significant health burden to the Chamorro population. We tested the hypothesis that quantitative proteomics might provide fresh insight into this enigmatic illness by analyzing proteins resistant to surfactant extraction from patients with Alzheimer's disease (AD) or PDC and their matched controls using isobaric tags for relative and absolute quantification. In addition to the expected increase in abnormal frontal cortical Abeta peptides, tau, ubiquitin, and apolipoprotein E in AD, and tau in PDC, we identified alpha-synuclein (SNCA) as a major abnormal protein in PDC but not AD. We confirmed our isobaric tags for relative and absolute quantification findings by enzyme-linked immunosorbent assay in frontal and temporal cortices. We extended our assays to include a limited number of cases of progressive supranuclear palsy (PSP) and dementia with Lewy bodies; we observed increased abnormal tau but not SNCA in PSP, and abnormal SNCA in dementia with Lewy bodies that was quantitatively similar to PDC. Finally, soluble Abeta oligomers were selectively increased in AD but not PDC or PSP. These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy.
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Registered trials
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