ArticleBlood2008
Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Defective cell-autonomous signalling and antigenic polyreactivity of B-cell receptors from chronic lymphocytic leukaemia stereotyped subset 1.Nature communications · 2025Article
- Stereotyped B-Cell Receptor Immunoglobulins in B-Cell Lymphomas.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- Prevalence of IGLV3-21R110 among familial CLL: a retrospective study of 45 cases.Blood advances · 2022Article
- Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements.Frontiers in oncology · 2022Article
- Matrix-assisted laser desorption ionization mass spectrometry profiling of plasma exosomes evaluates osteosarcoma metastasis.iScience · 2021Article
- Secretory IgM Exacerbates Tumor Progression by Inducing Accumulations of MDSCs in Mice.Cancer immunology research · 2018Article
- Host virus and pneumococcus-specific immune responses in high-count monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia: implications for disease progression.Haematologica · 2017Article
- Altered N-Linked Glycosylation in Follicular Lymphoma and Chronic Lymphocytic Leukemia: Involvement in Pathogenesis and Potential Therapeutic Targeting.Frontiers in immunology · 2017Review
- Transitional B Cells in Early Human B Cell Development - Time to Revisit the Paradigm?Frontiers in immunology · 2016Article
- The pathogenesis of chronic lymphocytic leukemia.Annual review of pathology · 2014Review
- A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi.The Journal of experimental medicine · 2013Article
- Article
- Article
- Immunoglobulin gene repertoire in chronic lymphocytic leukemia: insight into antigen selection and microenvironmental interactions.Mediterranean journal of hematology and infectious diseases · 2012Article
- Analyses of recombinant stereotypic IGHV3-21-encoded antibodies expressed in chronic lymphocytic leukemia.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- From pathogenesis to treatment of chronic lymphocytic leukaemia.Nature reviews. Cancer · 2010Review
- Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance.Journal of translational medicine · 2009Review
- Use of similar immunoglobulin VH gene segments by MALT lymphomas of the ocular adnexa.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2009Article
- Relative seroprevalence of human herpes viruses in patients with chronic lymphocytic leukaemia.European journal of clinical investigation · 2009Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We analyzed the immunoglobulin (Ig) variable heavy (IGHV) and variable light chain genes used by leukemia cells of 258 unrelated patients with chronic lymphocytic leukemia (CLL) found to express unmutated Ig heavy chains (IgH) encoded by a 51p1 allele of IGHV1-69 among 1846 CLL patients examined. We found each had at least 98% homology to an identified germline IGKV or IGLV gene. Within the 258 IgH, we identified heavy chain CDR3 (HCDR3) motifs encoded by certain unmutated IGHD and IGHJ genes with restricted reading frames. Frequent and restricted use of particular IGKV and IGLV genes revealed nonstochastic pairing of disparate Ig light chains (IgL) with IgH that had restricted HCDR3 motifs designated CLL69A, -B, -C, and -D. Eighty-six percent (19/22) of CLL cases that expressed motif CLL69B encoded by IGHD2-2/IGHJ6 had distinctive IgL encoded by IGKV1-39. Similarly, 83% (5/6) of samples with motif CLL69D encoded by IGHD2-2/IGHJ6 expressed IGKV3-11, 100% (25/25) with motif CLL69A encoded by IGHD3-16/IGHJ3 used IGKV3-20, and 77% (10/13) with motif CLL69C encoded by IGHD3-3/IGHJ6 expressed IGLV3-9. This study reveals nonstochastic pairing of IgH with particular IgL that is predicated upon Ig HCDR3 structure, providing compelling evidence for selection of antibodies expressed in CLL by conventional antigens.
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