ArticleProceedings of the National Academy of Sciences of the United States of America2007
Simulation of two-dimensional infrared spectroscopy of amyloid fibrils.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Study of the γD-crystallin protein using two-dimensional infrared (2DIR) spectroscopy: experiment and simulation.The journal of physical chemistry. B · 2013Article
- A strongly absorbing class of non-natural labels for probing protein electrostatics and solvation with FTIR and 2D IR spectroscopies.The journal of physical chemistry. B · 2013Article
- Parallel β-sheet vibrational couplings revealed by 2D IR spectroscopy of an isotopically labeled macrocycle: quantitative benchmark for the interpretation of amyloid and protein infrared spectra.Journal of the American Chemical Society · 2012Article
- Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human γD-crystallin amyloid fibrils.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Probing amyloid fibril growth by two-dimensional near-ultraviolet spectroscopy.The journal of physical chemistry. B · 2011Article
- Coherent control protocol for separating energy-transfer pathways in photosynthetic complexes by chiral multidimensional signals.The journal of physical chemistry. A · 2011Article
- Two-dimensional ultraviolet (2DUV) spectroscopic tools for identifying fibrillation propensity of protein residue sequences.Angewandte Chemie (International ed. in English) · 2010Article
- Simulation of two-dimensional ultraviolet spectroscopy of amyloid fibrils.The journal of physical chemistry. B · 2010Article
- Discriminating early stage A{beta}42 monomer structures using chirality-induced 2DIR spectroscopy in a simulation study.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Probing the folding of mini-protein Beta3s by two-dimensional infrared spectroscopy; simulation study.PMC biophysics · 2010Article
- Strategies for extracting structural information from 2D IR spectroscopy of amyloid: application to islet amyloid polypeptide.The journal of physical chemistry. B · 2009Article
- Coherent multidimensional optical spectroscopy of excitons in molecular aggregates; quasiparticle versus supermolecule perspectives.Chemical reviews · 2009Review
- Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Tracking fiber formation in human islet amyloid polypeptide with automated 2D-IR spectroscopy.Journal of the American Chemical Society · 2008Article
- Two-dimensional spectroscopy at infrared and optical frequencies.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Multidimensional ultrafast spectroscopy special feature: multidimensional ultrafast spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We propose to use infrared coherent two-dimensional correlation spectroscopy (2DCS) to characterize the fibril structure of Ab42, the dominant composition of Ab deposit, which is crucial for investigating its toxicity and aggregation mechanism. By optimizing the pulse polarization configurations with a genetic algorithm combined with sensitivity analysis, we obtained signals with well resolved cross-peak features attributed to the couplings within and between different structural motifs. These signals may provide new constraints for refining of the currently available NMR structure. Two-dimensional correlation spectroscopy also can differentiate the turn structure of Ab42 and other Ab derivatives.
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