ArticleJournal of bacteriology2007
The archaeon Methanosarcina acetivorans contains a protein disulfide reductase with an iron-sulfur cluster.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Functional Studies and Revision of the NFAT-133/TM-123 Biosynthetic Pathway inACS chemical biology · 2022Article
- Biosynthesis of the Nuclear Factor of Activated T Cells Inhibitor NFAT-133 inACS chemical biology · 2020Article
- γ-Carboxymuconolactone decarboxylase: a novel cell cycle-related basal body protein in the early branching eukaryote Trichomonas vaginalis.Parasites & vectors · 2017Article
- Genetic basis for metabolism of methylated sulfur compounds in Methanosarcina species.Journal of bacteriology · 2015Article
- Reducing the genetic code induces massive rearrangement of the proteome.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Molecular characterization of the thioredoxin system from Methanosarcina acetivorans.The FEBS journal · 2014Article
- Redox-sensitive DNA binding by homodimeric Methanosarcina acetivorans MsvR is modulated by cysteine residues.BMC microbiology · 2013Article
- Assessment of the oxidant tolerance of Methanosarcina acetivorans.FEMS microbiology letters · 2013Article
- Extracytoplasmic function σ factors of the widely distributed group ECF41 contain a fused regulatory domain.MicrobiologyOpen · 2012Article
- Subunit D of RNA polymerase from Methanosarcina acetivorans contains two oxygen-labile [4Fe-4S] clusters: implications for oxidant-dependent regulation of transcription.The Journal of biological chemistry · 2012Article
- Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis.Chemistry & biology · 2011Article
- Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a novel plant-type ferredoxin/thioredoxin reductase-like protein from Methanosarcina acetivorans.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
- Function of Ech hydrogenase in ferredoxin-dependent, membrane-bound electron transport in Methanosarcina mazei.Journal of bacteriology · 2010Article
- Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).Molecular microbiology · 2009Article
- Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Methanosarcina acetivorans, a strictly anaerobic methane-producing species belonging to the domain Archaea, contains a gene cluster annotated with homologs encoding oxidative stress proteins. One of the genes (MA3736) is annotated as a gene encoding an uncharacterized carboxymuconolactone decarboxylase, an enzyme required for aerobic growth with aromatic compounds by species in the domain Bacteria. Methane-producing species are not known to utilize aromatic compounds, suggesting that MA3736 is incorrectly annotated. The product of MA3736, overproduced in Escherichia coli, had protein disulfide reductase activity dependent on a C(67)XXC(70) motif not found in carboxymuconolactone decarboxylase. We propose that MA3736 be renamed mdrA (methanosarcina disulfide reductase). Further, unlike carboxymuconolactone decarboxylase, MdrA contained an Fe-S cluster. Binding of the Fe-S cluster was dependent on essential cysteines C(67) and C(70), while cysteines C(39) and C(107) were not required. Loss of the Fe-S cluster resulted in conversion of MdrA from an inactive hexamer to a trimer with protein disulfide reductase activity. The data suggest that MdrA is the prototype of a previously unrecognized protein disulfide reductase family which contains an intermolecular Fe-S cluster that controls oligomerization as a mechanism to regulate protein disulfide reductase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.