SynthesisThorax2007
A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis.
Synthesis in Thorax, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Systematic review and meta-analysis of antigen detection tests for the diagnosis of tuberculosis.Clinical and vaccine immunology : CVI · 2011Pooled it
- Commercial serological tests for the diagnosis of active pulmonary and extrapulmonary tuberculosis: an updated systematic review and meta-analysis.PLoS medicine · 2011Pooled it
- Performance of purified antigens for serodiagnosis of pulmonary tuberculosis: a meta-analysis.Clinical and vaccine immunology : CVI · 2009Pooled it
- Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review.PLoS medicine · 2007Pooled it
- The Effect of Empiric Initiation of Treatment on Outcomes Among Patients Presenting With Extrapulmonary Mycobacterium Tuberculosis Infection in a Community Hospital Setting.Journal of community hospital internal medicine perspectives · 2026Article
- Antibodies as clinical tools for tuberculosis.Frontiers in immunology · 2023Review
- An improved algorithm for rapid diagnosis of pleural tuberculosis from pleural effusion by combined testing with GeneXpert MTB/RIF and an anti-LAM antibody-based assay.BMC infectious diseases · 2019Article
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- Article
- Detection of Tuberculosis in HIV Co-infected Individuals: Use of Multiple ELISA Responses to 38kDa, Lipoarabinomannan and ESAT- 6 of M. tuberculosis.Journal of clinical and diagnostic research : JCDR · 2016Article
- Head and Neck Tuberculosis: Scenario in a Tertiary Care Hospital of North Eastern India.Journal of clinical and diagnostic research : JCDR · 2016Article
- Protein array identification of protein markers for serodiagnosis of Mycobacterium tuberculosis infection.Scientific reports · 2015Article
- Advances in Diagnostic Assays for Tuberculosis.Cold Spring Harbor perspectives in medicine · 2015Review
- Evaluation of Anti-TBGL Antibody in the Diagnosis of Tuberculosis Patients in China.Journal of immunology research · 2015Article
- Serological diagnostic assays for HIV-associated tuberculosis in sub-Saharan Africa?Clinical and vaccine immunology : CVI · 2014Article
- Development of a POC test for TB based on multiple immunodominant epitopes of M. tuberculosis specific cell-wall proteins.PloS one · 2014Article
- Article
- Updated diagnosis and treatment of childhood tuberculosis.World journal of pediatrics : WJP · 2013Review
- Organ donation, discrimination after death, anti-vaccination sentiments, and tuberculosis management.Journal of bioethical inquiry · 2012Article
- Serological tests for the diagnosis of active tuberculosis: relevance for India.The Indian journal of medical research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional diagnostic tests for tuberculosis have several limitations and are often unhelpful in establishing the diagnosis of extrapulmonary tuberculosis. Although commercial serological antibody based tests are available, their usefulness in the diagnosis of extrapulmonary tuberculosis is unknown. A systematic review was conducted to assess the accuracy of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis. In a comprehensive search, 21 studies that reported data on sensitivity and specificity for extrapulmonary tuberculosis were identified. These studies evaluated seven different commercial tests, with Anda-TB IgG accounting for 48% of the studies. The results showed that (1) all commercial tests provided highly variable estimates of sensitivity (range 0.00-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (2) the Anda-TB IgG kit showed highly variable sensitivity (range 0.26-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (3) for all tests combined, sensitivity estimates for both lymph node tuberculosis (range 0.23-1.00) and pleural tuberculosis (range 0.26-0.59) were poor and inconsistent; and (4) there were no data to determine the accuracy of the tests in children or in patients with HIV infection, the two groups for which the test would be most useful. At present, commercial antibody detection tests for extrapulmonary tuberculosis have no role in clinical care or case detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.