ArticleNeuropharmacology2008
Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.
Article in Neuropharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Bee Pollen and Probiotics May Alter Brain Neuropeptide Levels in a Rodent Model of Autism Spectrum Disorders.Metabolites · 2022Article
- Astrocyte Signaling Gates Long-Term Depression at Corticostriatal Synapses of the Direct Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Gender Related Changes in Gene Expression Induced by Valproic Acid in A Mouse Model of Autism and the Correction by S-adenosyl Methionine. Does It Explain the Gender Differences in Autistic Like Behavior?International journal of molecular sciences · 2019Article
- Diverse actions of the modulatory peptide neurotensin on central synaptic transmission.The European journal of neuroscience · 2019Review
- Neurotensin speeds inhibition of dopamine neurons through temporal modulation of GABANeuropharmacology · 2018Article
- Neurotensinergic Excitation of Dentate Gyrus Granule Cells via Gαq-Coupled Inhibition of TASK-3 Channels.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neurotensin agonist attenuates nicotine potentiation to cocaine sensitization.Behavioral sciences (Basel, Switzerland) · 2014Article
- Endocannabinoid-dopamine interactions in striatal synaptic plasticity.Frontiers in pharmacology · 2012Article
- Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance.British journal of pharmacology · 2011Review
- Serotonin induces long-term depression at corticostriatal synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey.The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Neurotensin is a peptide that has been suggested to mimic the actions of antipsychotics, but little is known about how it affects synaptic transmission in the striatum, the major input nucleus of the basal ganglia. In this study we measured the effects of neurotensin on EPSCs from medium spiny projection neurons in the sensorimotor striatum, a region implicated in habit formation and control of motor sequences. We found that bath-applied neurotensin reduced glutamate release from presynaptic terminals, and that this effect required retrograde endocannabinoid signaling, as it was prevented by the CB1 cannabinoid receptor antagonist AM251. Neurotensin-mediated inhibition of striatal EPSCs was also blocked by antagonists of D2-like dopamine receptors and group I metabotropic glutamate receptors, as well as by intracellular calcium chelation and phospholipase C inhibition. These results suggest that neurotensin can indirectly engage an endocannabinoid-mediated negative feedback signal to control glutamatergic input to the basal ganglia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.