ArticleJournal of computational neuroscience2008
Dendritic action potentials connect distributed dendrodendritic microcircuits.
Article in Journal of computational neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- How the olfactory bulb maintains stable odor manifolds amid adaptation and representational drift.bioRxiv : the preprint server for biology · 2026Article
- Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons.eLife · 2022Article
- Anatomical and Functional Connectivity at the Dendrodendritic Reciprocal Mitral Cell-Granule Cell Synapse: Impact on Recurrent and Lateral Inhibition.Frontiers in neural circuits · 2022Article
- Predicting brain organization with a computational model: 50-year perspective on lateral inhibition and oscillatory gating by dendrodendritic synapses.Journal of neurophysiology · 2020Review
- Pharmacological manipulation of the olfactory bulb modulates beta oscillations: testing model predictions.Journal of neurophysiology · 2018Article
- A coupled-oscillator model of olfactory bulb gamma oscillations.PLoS computational biology · 2017Article
- Biophysical constraints on lateral inhibition in the olfactory bulb.Journal of neurophysiology · 2016Article
- Odor Experience Facilitates Sparse Representations of New Odors in a Large-Scale Olfactory Bulb Model.Frontiers in neuroanatomy · 2016Article
- Functional differentiation of cholinergic and noradrenergic modulation in a biophysical model of olfactory bulb granule cells.Journal of neurophysiology · 2015Article
- Synaptic clusters function as odor operators in the olfactory bulb.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Sensory-evoked perturbations of locomotor activity by sparse sensory input: a computational study.Journal of neurophysiology · 2015Article
- Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding.PloS one · 2015Article
- Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- How neurogenesis finds its place in a hardwired sensory system.Frontiers in neuroscience · 2014Review
- Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.Frontiers in computational neuroscience · 2014Article
- Emergence in the central nervous system.Cognitive neurodynamics · 2013Article
- A model of cholinergic modulation in olfactory bulb and piriform cortex.Journal of neurophysiology · 2013Article
- A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Sparse distributed representation of odors in a large-scale olfactory bulb circuit.PLoS computational biology · 2013Article
- Noradrenergic and cholinergic modulation of olfactory bulb sensory processing.Frontiers in behavioral neuroscience · 2012Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Lateral inhibition of cells surrounding an excited area is a key property of sensory systems, sharpening the preferential tuning of individual cells in the presence of closely related input signals. In the olfactory pathway, a dendrodendritic synaptic microcircuit between mitral and granule cells in the olfactory bulb has been proposed to mediate this type of interaction through granule cell inhibition of surrounding mitral cells. However, it is becoming evident that odor inputs result in broad activation of the olfactory bulb with interactions that go beyond neighboring cells. Using a realistic modeling approach we show how backpropagating action potentials in the long lateral dendrites of mitral cells, together with granule cell actions on mitral cells within narrow columns forming glomerular units, can provide a mechanism to activate strong local inhibition between arbitrarily distant mitral cells. The simulations predict a new role for the dendrodendritic synapses in the multicolumnar organization of the granule cells. This new paradigm gives insight into the functional significance of the patterns of connectivity revealed by recent viral tracing studies. Together they suggest a functional wiring of the olfactory bulb that could greatly expand the computational roles of the mitral-granule cell network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.