ReviewPharmaceutical research2008
The apoptosome: emerging insights and new potential targets for drug design.
Review in Pharmaceutical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Apoptosome Formation through Disruption of the K192-D616 Salt Bridge in the Apaf-1 Closed Form.ACS omega · 2021Article
- LncRNA PVT1 Mediates Antiapoptosis and 5-Fluorouracil Resistance via Increasing Bcl2 Expression in Gastric Cancer.Journal of oncology · 2019Article
- Apoptotic Protease Activating Factor-1 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase-9 Recruitment by Apaf-1.Oxidative medicine and cellular longevity · 2017Article
- Aberrant localization of apoptosis protease activating factor-1 in lipid raft sub-domains of diffuse large B cell lymphomas.Oncotarget · 2016Article
- Ursodeoxycholic acid induces apoptosis in hepatocellular carcinoma xenografts in mice.World journal of gastroenterology · 2015Article
- Apoptosis Phenomena in Squamous Cell Carcinomas and Adenocarcinomas of the Uterine Cervix.Pathology oncology research : POR · 2015Article
- Targeting apoptosis in autoimmune hepatitis.Digestive diseases and sciences · 2014Review
- Development of anticancer drugs based on the hallmarks of tumor cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- BCNU/PLGA microspheres: a promising strategy for the treatment of gliomas in mice.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2014Article
- LncRNAs: New Players in Apoptosis Control.International journal of cell biology · 2014Review
- Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells.Oncology letters · 2013Article
- Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential.Cell death and differentiation · 2012Article
- Myrtenal attenuates diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades.Cellular oncology (Dordrecht, Netherlands) · 2012Article
- Naringenin promote apoptosis in cerebrally implanted C6 glioma cells.Molecular and cellular biochemistry · 2010Article
- Increased expression but not sensitivity to Fas/CD95 in glioblastoma cells depleted of mitochondrial DNA.Experimental and therapeutic medicine · 2010Article
- Making sense of HDAC2 mutations in colon cancer.Gastroenterology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated, such as heart attack, stroke, liver failure, cancer and autoimmune diseases. Consequently, great interest has emerged in devising therapeutic strategies for regulating the key molecules involved in the life-and-death decision. Here we review recent progress in apoptosis-based pharmacological therapies and, in particular, we point out a possible role of the apoptosome as an emerging and promising pharmacological target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.