ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2007
Dissecting the mammalian synaptonemal complex using targeted mutations.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Unveiling novel insights into gene expression in monkey testes through single-nucleus-based analysis.Frontiers in cell and developmental biology · 2026Article
- Cyprinid Juji (Gobiocypris rarus) as a model fish to study germ cell development and gonadal differentiation.Communications biology · 2025Article
- Involvement of SYCP2L and TDRD3 gene variants on ovarian reserve and reproductive outcomes: a cross-sectional study.JBRA assisted reproduction · 2023Article
- Single-Cell RNA Sequencing of the Testis ofCells · 2022Article
- PLK1 depletion alters homologous recombination and synaptonemal complex disassembly events during mammalian spermatogenesis.Molecular biology of the cell · 2022Article
- Synaptonemal complex proteins modulate the level of genome integrity in cancers.Cancer science · 2021Review
- Disassembly of the synaptonemal complex in chicken oocytes analyzed by super-resolution microscopy.Chromosoma · 2019Article
- Spermatogenesis associated 22 is required for DNA repair and synapsis of homologous chromosomes in mouse germ cells.Andrology · 2017Article
- Evolutionary history of the mammalian synaptonemal complex.Chromosoma · 2016Review
- Holding it together: rapid evolution and positive selection in the synaptonemal complex of Drosophila.BMC evolutionary biology · 2016Article
- Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L.Human molecular genetics · 2015Article
- The T657C polymorphism on the SYCP3 gene is associated with recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2014Article
- SLX2 interacting with BLOS2 is differentially expressed during mouse oocyte meiotic maturation.Cell cycle (Georgetown, Tex.) · 2014Article
- Article
- Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.Molecular systems biology · 2013Article
- Integrative proteomic and transcriptomic analyses reveal multiple post-transcriptional regulatory mechanisms of mouse spermatogenesis.Molecular & cellular proteomics : MCP · 2013Article
- Meiotic cohesin SMC1β provides prophase I centromeric cohesion and is required for multiple synapsis-associated functions.PLoS genetics · 2013Article
- Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes.Journal of cell science · 2012Article
- Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.Open biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In many organisms completion of the first meiotic cell division depends on the correct assembly and disassembly of the synaptonemal complex (SC). This is a structure discovered a little over 50 years ago, which is formed by the close association of axes of homologous sister chromatid pairs. Its structure varies between organisms, although it retains a common tripartite organization in species as evolutionarily distant as budding yeast and humans. In mammals it is essential for crossover formation and completion of meiosis. Components of the mammalian SC have been identified only in the last 15 years, and mouse genetic approaches have started revealing the importance for this structure only in the past 5 years. Here we discuss the progress that has been made in the field of the mammalian SC and what approaches could be considered for its further study.
Indexed as
Identifiers
17674147What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.