ArticleCalcified tissue international2007
Bivariate linkage study of proximal hip geometry and body size indices: the Framingham study.
Article in Calcified tissue international, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Atypical Femoral Shaft Fractures in Female Bisphosphonate Users Were Associated with an Increased Anterolateral Femoral Bow and a Thicker Lateral Cortex: A Case-Control Study.BioMed research international · 2017Article
- Effects of Hip Geometry on Fracture Patterns of Proximal Femur.The archives of bone and joint surgery · 2016Article
- Genetic regulation of bone strength: a review of animal model studies.BoneKEy reports · 2015Review
- Article
- Functional interactions among morphologic and tissue quality traits define bone quality.Clinical orthopaedics and related research · 2011Review
- How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging.Age (Dordrecht, Netherlands) · 2011Review
- Molecular genetic studies of gene identification for osteoporosis: the 2009 update.Endocrine reviews · 2010Review
- Genetically determined phenotype covariation networks control bone strength.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Interindividual variation in functionally adapted trait sets is established during postnatal growth and predictable based on bone robustness.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2009Article
- Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2009Article
- Article
- Systems analysis of bone.Wiley interdisciplinary reviews. Systems biology and medicineReview
- A genome wide linkage scan of metacarpal size and geometry in the Framingham Study.American journal of human biology : the official journal of the Human Biology CouncilArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Femoral geometry and body size are both characterized by substantial heritability. The purpose of this study was to discern whether hip geometry and body size (height and body mass index, BMI) share quantitative trait loci (QTL). Dual-energy X-ray absorptiometric scans of the proximal femur from 1,473 members in 323 pedigrees (ages 31-96 years) from the Framingham Osteoporosis Study were studied. We measured femoral neck length, neck-shaft angle, subperiosteal width (outer diameter), cross-sectional bone area, and section modulus, at the narrowest section of the femoral neck (NN), intertrochanteric (IT), and femoral shaft (S) regions. In variance component analyses, genetic correlations (rho ( G )) between hip geometry traits and height ranged 0.30-0.59 and between hip geometry and BMI ranged 0.11-0.47. In a genomewide linkage scan with 636 markers, we obtained nominally suggestive linkages (bivariate LOD scores > or =1.9) for geometric traits and either height or BMI at several chromosomes (4, 6, 9, 15, and 21). Two loci, on chr. 2 (80 cM, BMI/shaft section modulus) and chr. X (height/shaft outer diameter), yielded bivariate LOD scores > or =3.0; although these loci were linked in univariate analyses with a geometric trait, neither was linked with either height or BMI. In conclusion, substantial genetic correlations were found between the femoral geometric traits, height and BMI. Linkage signals from bivariate linkage analyses of bone geometric indices and body size were similar to those obtained in univariate linkage analyses of femoral geometric traits, suggesting that most of the detected QTL primarily influence geometry of the hip.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.