ArticleVirchows Archiv : an international journal of pathology2007
Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The role and mechanisms of the HIF-1 signaling pathway in LC-COPD.Journal of cancer research and clinical oncology · 2025Review
- An antioxidant ameliorates allergic airway inflammation by inhibiting HDAC 1 via HIF-1α/VEGF axis suppression in mice.Scientific reports · 2023Article
- Stromal Changes in Colon Blastomogenesis Associated with Development of Hypoxia in the Foci of Dysplasia.Bulletin of experimental biology and medicine · 2023Article
- Expression of HIF-1α in pediatric asthmatic patients.Multidisciplinary respiratory medicine · 2023Article
- The Problem of Vascularization of Precancerous Lesions of the Colon and Development of Hypoxia at the Incipient Stages of Blastomogenesis.Bulletin of experimental biology and medicine · 2022Article
- HIF-1α Stabilization in Flagellin-Stimulated Human Bronchial Cells Impairs Barrier Function.Cells · 2022Article
- Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer.Frontiers in oncology · 2022Review
- Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway.Molecular medicine (Cambridge, Mass.) · 2021Article
- Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program.JCI insight · 2021Article
- Influence of Hypoxia on the Epithelial-Pathogen Interactions in the Lung: Implications for Respiratory Disease.Frontiers in immunology · 2021Review
- The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host.International journal of molecular sciences · 2020Review
- COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1α mediated tumor angiogenesis and proliferation.Oncotarget · 2018Article
- Nominal carbonic anhydrase activity minimizes airway-surface liquid pH changes during breathing.Physiological reports · 2018Article
- Pulmonary Microvascular Blood Flow in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The MESA COPD Study.American journal of respiratory and critical care medicine · 2015Article
- Cigarette smoke extract induces a phenotypic shift in epithelial cells; involvement of HIF1α in mesenchymal transition.PloS one · 2014Article
- Optical detection of preneoplastic lesions of the central airways.ISRN oncology · 2012Article
- Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.PloS one · 2012Article
- Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease.Nitric oxide : biology and chemistry · 2011Review
- Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium.The Journal of pathology · 2011Article
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In airway remodeling that occurs in association with chronic obstructive pulmonary disease (COPD), the relationship between the subepithelium and structural changes of the bronchial epithelium is not well defined. To investigate whether the subepithelium and epithelium undergo remodeling as an integrated unit, we performed morphological examination of 55 bronchial biopsy specimens obtained from explanted or resected lungs from tobacco smokers with COPD. Our results indicate that reticular basement membrane (RBM) thickness is increased and the subepithelial microvascular bed is reduced in association with progression from the normal epithelium to squamous metaplasia. Subsequent bronchial epithelial transformation to dysplasia is characterized by differential subepithelial remodeling with normalization of RBM thickness and subepithelial blood vessel density. Because fibrous remodeling of the subepithelium could limit delivery of nutrients and oxygen to the epithelium, we assessed expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and carbonic anhydrase IX (CA IX) as markers of cellular hypoxia. The number of HIF-1alpha-positive epithelial cells increased with progression of epithelial structural changes, RBM thickness, and reduction in blood vessels in the subepithelium. These findings suggest that the HIF-1alpha pathway is activated in response to subepithelial remodeling and contributes to progressive premalignant epithelial lesions in the airways of tobacco smokers with chronic airway inflammation.
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Registered trials
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