ArticleImmunogenetics2007
Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii).
Article in Immunogenetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- Vincristine chemotherapy trials and pharmacokinetics in tasmanian devils with tasmanian devil facial tumor disease.PloS one · 2013Trial
- Best genome sequencing strategies for annotation of complex immune gene families in wildlife.GigaScience · 2022Article
- Article
- The ecology and evolution of wildlife cancers: Applications for management and conservation.Evolutionary applications · 2020Article
- Lessons learnt from the Tasmanian devil facial tumour regarding immune function in cancer.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- The devil is in the details: Genomics of transmissible cancers in Tasmanian devils.PLoS pathogens · 2018Article
- Article
- Genetic variation of major histocompatibility complex genes in the endangered red-crowned crane.Immunogenetics · 2017Article
- Present Yourself! By MHC Class I and MHC Class II Molecules.Trends in immunology · 2016Review
- A Sixth Modality of Infectious Disease: Contagious Cancer from Devils to Clams and Beyond.PLoS pathogens · 2016Review
- Contrasting evolutionary histories of MHC class I and class II loci in grouse--effects of selection and gene conversion.Heredity · 2016Article
- A second transmissible cancer in Tasmanian devils.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The identification of immune genes in the milk transcriptome of the Tasmanian devil (Sarcophilus harrisii).PeerJ · 2016Article
- Immunomics of the koala (Phascolarctos cinereus).Immunogenetics · 2015Article
- Diversity in the Toll-like receptor genes of the Tasmanian devil (Sarcophilus harrisii).Immunogenetics · 2015Article
- Characterisation of non-classical MHC class I genes in the Tasmanian devil (Sarcophilus harrisii).Immunogenetics · 2014Article
- Cancer. Hiding in plain view--an ancient dog in the modern world.Science (New York, N.Y.) · 2014Article
- Low major histocompatibility complex diversity in the Tasmanian devil predates European settlement and may explain susceptibility to disease epidemics.Biology letters · 2013Article
- Characterisation of four major histocompatibility complex class II genes of the koala (Phascolarctos cinereus).Immunogenetics · 2013Article
- Low MHC class II diversity in the Tasmanian devil (Sarcophilus harrisii).Immunogenetics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Tasmanian devil (Sarcophilus harrisii) is currently threatened by an emerging wildlife disease, devil facial tumour disease. The disease is decreasing devil numbers dramatically and may lead to the extinction of the species. At present, nothing is known about the immune genes or basic immunology of the devil. In this study, we report the construction of the first genetic library for the Tasmanian devil, a spleen cDNA library, and the isolation of full-length MHC Class I and Class II genes. We describe six unique Class II beta chain sequences from at least three loci, which belong to the marsupial Class II DA gene family. We have isolated 13 unique devil Class I sequences, representing at least seven Class I loci, two of which are most likely non-classical genes. The MHC Class I sequences from the devil have little heterogeneity, indicating recent divergence. The MHC genes described here are most likely involved in antigen presentation and are an important first step for studying MHC diversity and immune response in the devil.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.