ArticleMedical oncology (Northwood, London, England)2007
The influence of parental age and gender on anticipation in familial B-cell malignancies.
Article in Medical oncology (Northwood, London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Risk of hematological malignancies and anticipation in the families of patients with non-Hodgkin and Hodgkin lymphoma.Frontiers in oncology · 2025Article
- Occurrence of renal cell carcinoma and hematologic malignancies (predominantly lymphoid) in individuals and in families.Familial cancer · 2016Article
- Familial leukemias.Current treatment options in oncology · 2015Review
- Perinatal and family risk factors for Hodgkin lymphoma in childhood through young adulthood.American journal of epidemiology · 2012Article
- Anticipation in families with chronic lymphocytic leukemia and other lymphoproliferative disorders.Translational oncogenomics · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anticipation occurs when a disease manifests at an earlier age and/or with an increased clinical severity in the next generation. Its relationship with parental age and gender is relevant to the patterns of genetic transmission of familial B-cell neoplasms. One hundred and sixty pairs [44 non-Hodgkin's lymphoma (NHL), 38 Hodgkin's disease (HD), 48 HD/NHL, and 30 CLL] were analyzed retrospectively for presence of anticipation in paternal (PT), maternal (MT), and overall transmission. Overall mean anticipation measured -23.0 yr, and varied between -18.93 and -26.46 yr with no significant difference among different diseases, except between CLL and mixed HD/NHL (mean difference -7.68 yr, p = 0.03). A significant Pearson correlation (PC) between the parental age at conception and anticipation was found for all malignancies (PC = -0.339, p < 0.0001), with the exception of mixed HD/NHL pairs of MT. Higher PCs were observed with PT than MT for all diseases. Anticipation manifests in all familial B-cell malignancies analyzed and it correlates with the parental age at conception. Although less prominent than with neurological disease, this phenomenon indicates a possible germline inheritance of B-cell malignancies and a common genetic basis for HD and NHL.
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