ArticleAmerican journal of respiratory and critical care medicine2007
Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma.
Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 90 citations in OpenAlex.
- Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions.Particle and fibre toxicology · 2010Trial
- Variants in TGFB1, dust mite exposure, and disease severity in children with asthma.American journal of respiratory and critical care medicine · 2009Trial
- The role of TGF-β1 C-509T and TGF-β1 T869C polymorphisms in susceptibility to tuberculosis infection in a Sudanese population: a case-control study.BMC infectious diseases · 2025Article
- Role of the TGF-β cytokine and its gene polymorphisms in asthma etiopathogenesis.Frontiers in allergy · 2025Review
- Life Course of Asthma.Advances in experimental medicine and biology · 2023Article
- The role of gene-ambient air pollution interactions in paediatric asthma.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Review
- Eosinophilic esophagitis: Immune mechanisms and therapeutic targets.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Review
- Mechanisms of Immunotoxicity: Stressors and Evaluators.International journal of molecular sciences · 2021Review
- TGF-β: The missing link in obesity-associated airway diseases?Current research in pharmacology and drug discovery · 2021Review
- CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions.NAR genomics and bioinformatics · 2020Article
- Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children-An Overview in Research Insights of the Last Few Years.International journal of environmental research and public health · 2020Review
- TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis.Mucosal immunology · 2020Article
- Genetic evidence for the role of transforming growth factor-β in atopic phenotypes.Current opinion in immunology · 2019Review
- Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma.Frontiers in pediatrics · 2019Review
- Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.Clinical epigenetics · 2018Article
- RISK EFFECTS OF NEAR-ROADWAY POLLUTANTS AND ASTHMA STATUS ON BRONCHITIC SYMPTOMS IN CHILDREN.Environmental epidemiology (Philadelphia, Pa.) · 2018Article
- TGF-β1 Suppresses IL-33-Induced Mast Cell Function.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Effects of Childhood Asthma on the Development of Obesity among School-aged Children.American journal of respiratory and critical care medicine · 2017Article
- Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationaleTransforming growth factor (TGF)-beta1 is involved in airway inflammation and remodeling, two key processes in asthma pathogenesis. Tobacco smoke and traffic emissions induce airway inflammation and modulate TGF-beta1 gene expression. We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures.
objectivesWe tested these hypotheses among 3,023 children who participated in the Children's Health Study.
methodsTagging single-nucleotide polymorphisms rs4803457 C>T and C-509T (a functional promoter polymorphism) accounted for 94% of the haplotype diversity of the upstream region. Exposure to maternal smoking in utero was based on smoking by biological mother during pregnancy. Residential distance from nearest freeway was calculated based on residential address at study entry. MEASUREMENTS AND MAIN
resultsChildren with the -509TT genotype had a 1.8-fold increased risk of early persistent asthma (95% confidence interval [CI], 1.11-2.95). This association varied marginally significantly by in utero exposure to maternal smoking. Compared with children with the -509CC/CT genotype with no in utero exposure to maternal smoking, those with the -509TT genotype with such exposure had a 3.4-fold increased risk of early persistent asthma (95% CI, 1.46-7.80; interaction, P = 0.11). The association between TGF-beta1 C-509T and lifetime asthma varied by residential proximity to freeways (interaction P = 0.02). Children with the -509TT genotype living within 500 m of a freeway had over three-fold increased lifetime asthma risk (95% CI, 1.29-7.44) compared with children with CC/CT genotype living > 1500 m from a freeway.
conclusionsChildren with the TGF-beta1 -509TT genotype are at increased risk of asthma when they are exposed to maternal smoking in utero or to traffic-related emissions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.