ArticleThe Journal of physiology2007
Potassium, Na+,K+-pumps and fatigue in rat muscle.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Lactic acidosis: implications for human exercise performance.European journal of applied physiology · 2025Review
- Modified creatine greatly increases the performance of skeletal and smooth muscles.Biochemistry and biophysics reports · 2025Article
- Exercise and fatigue: integrating the role of KEuropean journal of applied physiology · 2023Review
- The role of AMPK in regulation of NaJournal of muscle research and cell motility · 2021Review
- Synchronization Modulation of Na/K Pumps Induced Membrane Potential Hyperpolarization in Both Physiological and Hyperkalemic Conditions.The Journal of membrane biology · 2019Article
- K⁺ and Rb⁺ Affinities of the Na,K-ATPase α₁ and α₂ Isozymes: An Application of ICP-MS for Quantification of Na⁺ Pump Kinetics in Myofibers.International journal of molecular sciences · 2018Article
- Muscle phenotype is related to motor unit behavior of the vastus lateralis during maximal isometric contractions.Physiological reports · 2018Article
- Limitations in intense exercise performance of athletes - effect of speed endurance training on ion handling and fatigue development.The Journal of physiology · 2017Review
- Diaphragm Muscle Adaptation to Sustained Hypoxia: Lessons from Animal Models with Relevance to High Altitude and Chronic Respiratory Diseases.Frontiers in physiology · 2016Review
- Muscle Fatigue Affects the Interpolated Twitch Technique When Assessed Using Electrically-Induced Contractions in Human and Rat Muscles.Frontiers in physiology · 2016Article
- Regulation of Potassium Homeostasis.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Extracellular Ca2+-induced force restoration in K+-depressed skeletal muscle of the mouse involves an elevation of [K+]i: implications for fatigue.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Quantification of Na+,K+ pumps and their transport rate in skeletal muscle: functional significance.The Journal of general physiology · 2013Review
- Effects of high-frequency stimulation and doublets on dynamic contractions in rat soleus muscle exposed to normal and high extracellular [K(+)].Physiological reports · 2013Article
- Stress-induced increase in muscle force: truth or myth?The Journal of physiology · 2013Article
- Relationship between membrane Cl- conductance and contractile endurance in isolated rat muscles.The Journal of physiology · 2013Article
- Tissue-specific role of the Na,K-ATPase α2 isozyme in skeletal muscle.The Journal of biological chemistry · 2013Article
- Na+,K+-pump stimulation improves contractility in isolated muscles of mice with hyperkalemic periodic paralysis.The Journal of general physiology · 2011Article
- Ion fluxes, transmembrane potential, and osmotic stabilization: a new dynamic electrophysiological model for eukaryotic cells.European biophysics journal : EBJ · 2011Article
- Effects of acidification and increased extracellular potassium on dynamic muscle contractions in isolated rat muscles.The Journal of physiology · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During contractile activity, skeletal muscles undergo a net loss of cytoplasmic K(+) to the interstitial space. During intense exercise, plasma K(+) in human arterial blood may reach 8 mm, and interstitial K(+) 10-12 mm. This leads to depolarization, loss of excitability and contractile force. However, little is known about the effects of these physiological increases in extracellular K(+) ([K(+)](o)) on contractile endurance. Soleus muscles from 4-week-old rats were mounted on transducers for isometric contractions in Krebs-Ringer bicarbonate buffer containing 4-10 mm K(+), and endurance assessed by recording the rate of force decline during continuous stimulation at 60 Hz. Increasing [K(+)](o) from 4 to 8 or 10 mm and equilibrating the muscles for 40 or 20 min augmented the rate of force decline 2.4-fold and 7.2-fold, respectively (P < 0.001). The marked loss of endurance elicited by exposure to 8 or 10 mm K(+) was alleviated or significantly reduced by stimulating the Na(+),K(+)-pumps by intracellular Na(+) loading, the beta(2)-agonist salbutamol, adrenaline, calcitonin gene related peptide, insulin or repeated excitation. In conclusion, excitation-induced increase in [K(+)](o) is an important cause of high-frequency fatigue, and the Na(+),K(+)-pumps are essential for the maintenance of contractile force in the physiological range of [K(+)](o). Recordings of contractile force during continuous stimulation at 8-10 mm K(+) may be used to analyse the effects of agents or conditions influencing the excitability of working isolated muscles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.