Evidence map›Paper›PMID 17673172›Full record

ArticleBiochemical and biophysical research communications2007

The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae.

Ritu Pathak, Heidi M Blank, Jinbai Guo, Sarah Ellis, Michael Polymenis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ritu PathakDepartment of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, TX 77843, USA.
Heidi M Blank
Jinbai Guo
Sarah Ellis
Michael Polymenis
Texas A&M University · US

Funding

Coordination of Cell Growth with Cell DivisionR01GM062377 · NIGMS · TEXAS A&M UNIVERSITY SYSTEM · PI POLYMENIS, MICHAEL S · 2001 to 2005
$1.1M
NIGMS NIH HHS R01 GM062377NIGMS NIH HHS R01-GM062377
6 · The paper itself

Abstract

Initiation of cell division is controlled by an irreversible switch. In Saccharomyces cerevisiae degradation of the Sic1p protein, an inhibitor of mitotic cyclin/cyclin-dependent kinase complexes, takes place before initiation of DNA replication, at a point called START. Sic1p is phosphorylated by multiple kinases, which can differentially affect the stability of Sic1p. How phosphorylations that stabilize Sic1p are reversed is unknown. Here we show that the Dcr2p phosphatase functionally and physically interacts with Sic1p. Over-expression of Dcr2p destabilizes Sic1p and leads to phenotypes associated with destabilized Sic1p, such as genome instability. Our results identify a novel factor that affects the stability of Sic1p, possibly contributing to mechanisms that trigger initiation of cell division.

Indexed as

Cell CycleChromosomal InstabilityCyclin-Dependent Kinase Inhibitor ProteinsPhenotypePhosphoric Monoester HydrolasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCyclin-Dependent Kinase Inhibitor ProteinsDcr2 protein, S cerevisiaePhosphoric Monoester HydrolasesSaccharomyces cerevisiae ProteinsSIC1 protein, S cerevisiae

Identifiers

PMID17673172
PMCPMC2031908
OpenAlexW2026333473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.