Trial reportCognitive, affective & behavioral neuroscience2007
Differential effects of scopolamine and lorazepam on working memory maintenance versus manipulation processes.
Trial report in Cognitive, affective & behavioral neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The effect of scopolamine on memory and attention: a systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Individual Differences in Working Memory Capacity Predict Topiramate-Related Cognitive Deficits.Journal of clinical psychopharmacology · 2018Trial
- Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram.Psychopharmacology · 2015Trial
- Cognitive effects of intramuscular ketamine and oral triazolam in healthy volunteers.Psychopharmacology · 2013Trial
- Galantamine improves sustained attention in chronic cocaine users.Experimental and clinical psychopharmacology · 2011Trial
- Preclinical animal anxiety research - flaws and prejudices.Pharmacology research & perspectives · 2016Review
- On the relationship between persistent delay activity, repetition enhancement and priming.Frontiers in psychology · 2014Review
- Encoding of rat working memory by power of multi-channel local field potentials via sparse non-negative matrix factorization.Neuroscience bulletin · 2013Article
- Acute cognitive effects of high doses of dextromethorphan relative to triazolam in humans.Drug and alcohol dependence · 2013Article
- Working memory in the odor span task: effects of chlordiazepoxide, dizocilpine (MK801), morphine, and scopolamine.Psychopharmacology · 2013Article
- Comparison of cognitive performance in methadone maintenance patients with and without current cocaine dependence.Drug and alcohol dependence · 2012Article
- Working memory span capacity improved by a D2 but not D1 receptor family agonist.Behavioural brain research · 2011Article
- Does neuroimaging research examining the pathophysiology of posttraumatic stress disorder require medication-free patients?Journal of psychiatry & neuroscience : JPN · 2010Review
- Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers.Psychopharmacology · 2009Article
- Delirium in early-stage alzheimer's disease: enhancing cognitive reserve as a possible preventive measure.Journal of gerontological nursing · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Between-study comparisons of benzodiazepine and anticholinergic drugs on working memory suggest that anticholinergics may produce greater impairment in maintenance processes, whereas benzodiazepines may produce greater impairment in manipulation processes. This study directly compared acute effects ofthe benzodiazepine lorazepam (1.0 and 2.0 mg/70 kg, orally administered) and the anticholinergic scopolamine (0.25 and 0.50 mg/70 kg, subcutaneously administered) on working memory maintenance (storage and rehearsal) and manipulation processes in a placebo-controlled, double-dummy, double-blind, crossover design in 20 healthy volunteers. Using a modified Sternberg paradigm, storage, rehearsal, and manipulation processes were parametrically manipulated by varying memory load, delay between stimulus presentation and test, and number of operations performed on the letter strings, respectively, while controlling for drug effects on nonmemory processes. As predicted, the results suggested greater impairment in maintenance processes (rehearsal) with scopolamine than with lorazepam and greater impairment in manipulation processes with lorazepam than with scopolamine. In addition, the results suggested greater overall slowing of working memory processes with lorazepam.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.