ArticleWiener klinische Wochenschrift2007
Histopathology of columnar-lined esophagus in patients with gastroesophageal reflux disease.
Article in Wiener klinische Wochenschrift, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Histologic Features Associated With Columnar-lined Esophagus in Distal Esophageal and Gastroesophageal Junction (GEJ) Biopsies From GERD Patients: A Community-based Population Study.The American journal of surgical pathology · 2016Article
- Cardiac mucosa at the gastroesophageal junction: An Eastern perspective.World journal of gastroenterology · 2015Article
- Review on novel concepts of columnar lined esophagus.Wiener klinische Wochenschrift · 2013Review
- Robot-assisted laparoscopic cardiomyotomy.Wiener klinische Wochenschrift · 2009Article
- On: laparoscopic fundoplication: Nissen versus Toupet two-year outcome of a prospective randomized study of 200 patients regarding preoperative esophageal motility [Surg Endosc 22(1):21-30].Surgical endoscopy · 2008Article
- Histopathology of the endoscopic esophagogastric junction in patients with gastroesophageal reflux disease.Wiener klinische Wochenschrift · 2008Article
- Videoendoscopy and histopathology of the esophagogastric junction in patients with gastroesophageal reflux disease.Wiener klinische Wochenschrift · 2007Article
- Chylous cyst formation following laparoscopic fundoplication.Wiener klinische Wochenschrift · 2007Article
- Cardiac mucosa indicates risk for Barrett esophagus.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe question of whether an endoscopically normal-appearing esophagogastric junction should be biopsied in patients with gastroesophageal reflux disease is controversial. We have addressed this issue using endoscopy and histopathology.
methodsA total of 114 consecutive patients (58 males) with symptoms of gastroesophageal reflux disease prospectively underwent endoscopy, including biopsy sampling from the esophagogastric junction. Endoscopically visible columnar-lined esophagus was defined by the presence of gastric-type mucosa above the level of the rise of the gastric folds. Histopathology was conducted using the Paull-Chandrasoma classification.
resultsOf the 114 patients, 85 (74.6%) had endoscopically visible columnar-lined esophagus of length < or =0.5 cm (n = 82), 1 cm (n = 2) and 7 cm (n = 1); 29 patients (25.4%) had a normal endoscopic junction. All patients had histopathologic columnar-lined esophagus. Intestinal metaplasia and low-grade dysplasia was identified in 26 (22.8%) and 5 (4.4%) individuals, respectively, and was not statistically different in endoscopically normal vs. abnormal junction (P = 0.408 for intestinal metaplasia, P = 0.775 for low grade dysplasia). Intestinal metaplasia was independent from endoscopic esophagitis (P = 0.398) and hiatal hernia (P = 0.405).
conclusionsColumnar-lined esophagus cannot be excluded by endoscopy. In patients with gastroesophageal reflux disease, biopsy sampling of normal-appearing junction is recommended for histopathologic exclusion of intestinal metaplasia and low-grade dysplasia.
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