ArticleMammalian genome : official journal of the International Mammalian Genome Society2007
Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Teratoma Development in 129.MOLF-Chr19 Mice Elicits Two Waves of Immune Cell Infiltration.International journal of molecular sciences · 2024Article
- Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Genome research · 2015Review
- Tumor loci and their interactions on mouse chromosome 19 that contribute to testicular germ cell tumors.BMC genetics · 2014Article
- Significance and therapeutic value of miRNAs in embryonal neural tumors.Molecules (Basel, Switzerland) · 2014Review
- Fetal cyclophosphamide exposure induces testicular cancer and reduced spermatogenesis and ovarian follicle numbers in mice.PloS one · 2014Article
- Article
- Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors.Cancer research · 2010Article
- The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients.Journal of ovarian research · 2009Article
- Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies.Genome research · 2008Article
- The role of dead-end in germ-cell tumor development.Annals of the New York Academy of Sciences · 2007Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here we report the identification of candidate disease genes from a CSS by using a combination of genetic and genomic approaches and by using knowledge about the germ cell tumor disease etiology. We used the CSS 129.MOLF-Chr19 chromosome substitution strain, in which males develop germ cell tumors of the testes at an extremely high rate. We were able to identify three protein-coding genes and one microRNA on chromosome 19 that have previously not been implicated to be testicular tumor susceptibility genes. Our findings suggest that changes in gene expression levels in the gonadal tissues of multiple genes from Chr 19 likely contribute to the high testicular germ cell tumor (TGCT) incidence of the 129.MOLF-Chr19 strain. Our data advance the use of CSS to identify disease susceptibility genes and demonstrate that the 129.MOLF-Chr19 strain serves as a useful model to elucidate the genetics and biology of germ cell transformation and tumor development.
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