ArticleThe Journal of clinical investigation2007
When EGF is offside, magnesium is wasted.
Article in The Journal of clinical investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 53 citations in OpenAlex.
- Evaluation of the usefulness of protocol-based magnesium supplementation for hypomagnesemia in patients with advanced or recurrent colorectal cancer treated with panitumumab.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Cardiovascular toxicity of tyrosine kinase inhibitors during cancer treatment: Potential involvement of TRPM7.Frontiers in cardiovascular medicine · 2023Review
- Hypomagnesemia and survival in patients with head and neck cancers who received primary concurrent chemoradiation.Cancer · 2021Article
- Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers.Head & neck · 2021Article
- Effect of prolonged omeprazole administration on segmental intestinal MgWorld journal of gastroenterology · 2020Article
- Hypomagnesemia and Survival in Patients with Ovarian Cancer Who Received Chemotherapy with Carboplatin.The oncologist · 2019Article
- Antacid attenuates the laxative action of magnesia in cancer patients receiving opioid analgesic.The Journal of pharmacy and pharmacology · 2016Article
- Epidermal growth factor, from gene organization to bedside.Seminars in cell & developmental biology · 2014Review
- Drug-induced impairment of renal function.International journal of nephrology and renovascular disease · 2014Review
- Chemotherapy-associated renal dysfunction.Nature reviews. Nephrology · 2009Review
- Regulation of magnesium reabsorption in DCT.Pflugers Archiv : European journal of physiology · 2009Review
- Molecular determinants of magnesium homeostasis: insights from human disease.Journal of the American Society of Nephrology : JASN · 2008Review
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Authors and funding
2 authors at 1 institution in 2 countries.
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Abstract
Our understanding of magnesium (Mg(2+)) regulation has recently been catapulted forward by the discovery of several disease loci for monogenic disorders of Mg(2+) homeostasis. In this issue of the JCI, Groenestege et al. report that their study of a rare inherited Mg(2+) wasting disorder in consanguineous kindred shows that EGF acts as an autocrine/paracrine magnesiotropic hormone (see the related article beginning on page 2260). EGF stimulates Mg(2+) reabsorption in the renal distal convoluted tubule (DCT) via engagement of its receptor on the basolateral membrane of DCT cells and activation of the Mg(2+) channel TRPM6 (transient receptor potential cation channel, subfamily M, member 6) in the apical membrane. These authors show that a point mutation in pro-EGF retains EGF secretion to the apical but not the basolateral membrane, disrupting this cascade and causing renal Mg(2+) wasting. This work is another seminal example of the power of the study of monogenic disorders in the quest to understand human physiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.