ArticleGenes and immunity2007
Superantigen-induced CD4+ T cell tolerance is associated with DNA methylation and histone hypo-acetylation at cytokine gene loci.
Article in Genes and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy.The Journal of infectious diseases · 2010Trial
- Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey.Nature reviews. Immunology · 2021Review
- Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.PLoS pathogens · 2018Article
- Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4Toxicology letters · 2016Article
- Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms.EMBO reports · 2014Article
- Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance.Molecular and cellular biology · 2014Article
- Induction and stability of the anergic phenotype in T cells.Seminars in immunology · 2013Review
- T-cell tolerance in cancer.Immunotherapy · 2013Review
- Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells.European journal of immunology · 2012Article
- De novo DNA methylation is required to restrict T helper lineage plasticity.The Journal of biological chemistry · 2012Article
- Molecular mechanisms of T-cell tolerance.Immunological reviews · 2011Review
- GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness.The FEBS journal · 2011Review
- The postnatal maternal environment affects autoimmune disease susceptibility in A/J mice.Cellular immunology · 2010Article
- Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Anergy is an important mechanism of peripheral tolerance in which T cells lose the capacity to produce proinflammatory cytokines such as interleukin-2 (IL-2) and interferon-gamma (IFNgamma). To determine whether the induction of T-cell anergy in vivo is associated with epigenetic changes that oppose cytokine gene expression, we measured DNA methylation and histone acetylation at the IL2 and IFNgamma loci in CD4+ T cells from mice tolerant to a viral superantigen. Tolerant T cells exhibited more DNA methylation and less histone acetylation at the regulatory regions of the IL2 and IFNgamma genes than effector T cells, which are able to produce IL-2 and IFNgamma. These data show that T-cell anergy in this model is associated with epigenetic modifications that oppose gene expression, and suggest that these mechanisms may be important in the maintenance of tolerance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.