ArticleClinical and vaccine immunology : CVI2007
Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-cell epitope level.
Article in Clinical and vaccine immunology : CVI, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Recombinant proteins expressed in Mycolicibacterium smegmatis enhance antibody-based detection of bovine tuberculosis.Veterinary research · 2026Article
- High-Throughput Sequencing of Nontuberculous Mycobacterial Flora andVeterinary sciences · 2025Article
- Challenges in diagnosing bovine tuberculosis through surveillance and characterization of Mycobacterium species in slaughtered cattle in Kolkata.BMC veterinary research · 2024Article
- The Presence ofMicroorganisms · 2024Article
- Detection ofFrontiers in microbiology · 2024Article
- Differences in skin test reactions to official and defined antigens in guinea pigs exposed to non-tuberculous and tuberculous bacteria.Scientific reports · 2023Article
- Article
- High-Specificity Test Algorithm for Bovine Tuberculosis Diagnosis in African Buffalo (Pathogens (Basel, Switzerland) · 2022Article
- Identification and Characterisation of Nontuberculous Mycobacteria in African Buffaloes (Microorganisms · 2022Article
- Culture-Independent PCR Detection and Differentiation ofPathogens (Basel, Switzerland) · 2022Article
- Infection of a Free-Living Wild Boar (Animals : an open access journal from MDPI · 2022Article
- Cell-Mediated Immunological Biomarkers and Their Diagnostic Application in Livestock and Wildlife Infected WithFrontiers in immunology · 2021Review
- SystemicPathogens (Basel, Switzerland) · 2020Article
- Detection of Wood Mice (Microorganisms · 2020Article
- Evaluation of Risk Factors Associated With Herds With an Increased Duration of Bovine Tuberculosis Breakdowns in Castilla y Leon, Spain (2010-2017).Frontiers in veterinary science · 2020Article
- Tuberculosis in Swiss captive Asian elephants: microevolution of Mycobacterium tuberculosis characterized by multilocus variable-number tandem-repeat analysis and whole-genome sequencing.Scientific reports · 2017Article
- Mycobacterium gordonae in Patient with Facial Ulcers, Nosebleeds, and Positive T-SPOT.TB Test, China.Emerging infectious diseases · 2017Article
- Proteomic characterisation of bovine and avian purified protein derivatives and identification of specific antigens for serodiagnosis of bovine tuberculosis.Clinical proteomics · 2017Article
- Non-tuberculous Mycobacteria in South African Wildlife: Neglected Pathogens and Potential Impediments for Bovine Tuberculosis Diagnosis.Frontiers in cellular and infection microbiology · 2017Article
- A review of risk factors for bovine tuberculosis infection in cattle in the UK and Ireland.Epidemiology and infection · 2016Review
Corrections and comments
- Erratum issuedDrijfhout, Jan Wouter [added]
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cross-reactivity between Mycobacterium kansasii ESAT-6 and CFP-10 homologues and their M. bovis counterparts can confound the interpretation of immunodiagnostic tests for tuberculosis. M. kansasii is a nontuberculous mycobacterial species cultured from skin test-positive cattle in Great Britain. Using peptides derived from M. bovis and M. kansasii ESAT-6 and CFP-10 regions that differ between these species, we investigated the species specificity and cross-reactivity at the level of individual bovine T-cell epitopes. Our results demonstrated that all peptides tested are fully cross-reactive, with the exception of one ESAT-6-derived peptide that harbored an M. bovis-specific epitope(s) when it was recognized in the context of bovine leukocyte antigen (BoLA)-DQ but that was cross-reactive with its M. kansasii homologues when it was restricted by BoLA-DR. This observation further highlights that prediction of species specificity by comparing sequence identity/homology alone is not sufficient and that individuals with diverse major histocompatibility complex constellations need to be tested to characterize the cross-reactivity or species specificity of peptide-based reagents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.