ArticleJournal of clinical microbiology2007
Sequential linezolid-resistant Staphylococcus epidermidis isolates with G2576T mutation.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Emergence of OptrA Gene Mediated Linezolid Resistance among Enterococcus Faecium: A Pilot Study from a Tertiary Care Hospital, India.International journal of molecular and cellular medicine · 2023Article
- Mechanisms of Linezolid Resistance Among Enterococci of Clinical Origin in Spain-Detection ofMicroorganisms · 2020Article
- Linezolid resistant coagulase negative staphylococci (LRCoNS) with novel mutations causing blood stream infections (BSI) in India.BMC infectious diseases · 2019Article
- Clostridium difficile isolates with high linezolid MICs harbor the multiresistance gene cfr.Antimicrobial agents and chemotherapy · 2015Article
- Cfr-mediated linezolid-resistance among methicillin-resistant coagulase-negative staphylococci from infections of humans.PloS one · 2013Article
- The emerging problem of linezolid-resistant Staphylococcus.The Journal of antimicrobial chemotherapy · 2013Review
- Resistance to linezolid caused by modifications at its binding site on the ribosome.Antimicrobial agents and chemotherapy · 2012Review
- Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.BMC genomics · 2011Article
- Detection of new mutations conferring resistance to linezolid in glycopeptide-intermediate susceptibility Staphylococcus hominis subspecies hominis circulating in an intensive care unit.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
- Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance.Genome research · 2009Article
- Endemic linezolid-resistant Staphylococcus epidermidis in a critical care unit.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Molecular epidemiology of coagulase-negative bloodstream isolates: detection of Staphylococcus epidermidis ST2, ST7 and linezolid-resistant ST23.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on an analysis of sequential isolates of Staphylococcus epidermidis from cultures of blood obtained from a patient with acute myeloid leukemia while the patient was receiving linezolid treatment. All 12 isolates had a linezolid MIC of 32 microg/ml. A 420-bp domain V region of the 23S rRNA gene from all isolates was amplified, and their nucleotide sequences were determined. A G2576T mutation was identified in all isolates. It was estimated that 67% of the 23S rRNA genes carried this mutation. This is the first report of the failure of linezolid treatment for Staphylococcus epidermidis bacteremia associated with a G2576T mutation in an immunocompromised patient.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.