ArticleJournal of virology2007
The structure of a putative scaffolding protein of immature poxvirus particles as determined by electron microscopy suggests similarity with capsid proteins of large icosahedral DNA viruses.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Scanning transmission electron tomography to study virus assembly: Review for the retirement of Paul Walther.Journal of microscopy · 2025Review
- Poxvirus under the eyes of electron microscope.Applied microscopy · 2022Review
- Assembly mechanism of the pleomorphic immature poxvirus scaffold.Nature communications · 2022Article
- The RNA-Binding Protein of a Double-Stranded RNA Virus Acts like a Scaffold Protein.Journal of virology · 2018Article
- Deletion of the Chemokine Binding Protein Gene from the Parapoxvirus Orf Virus Reduces Virulence and Pathogenesis in Sheep.Frontiers in microbiology · 2017Article
- Poxvirus membrane biogenesis.Virology · 2015Review
- Membrane remodeling by the double-barrel scaffolding protein of poxvirus.PLoS pathogens · 2011Article
- Viral life cycles captured in three-dimensions with electron microscopy tomography.Current opinion in virology · 2011Review
- Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13.Structure (London, England : 1993) · 2011Article
- Pass the jelly rolls.Structure (London, England : 1993) · 2011Article
- The closest relatives of icosahedral viruses of thermophilic bacteria are among viruses and plasmids of the halophilic archaea.Journal of virology · 2009Article
- Assembly and disassembly of the capsid-like external scaffold of immature virions during vaccinia virus morphogenesis.Journal of virology · 2009Article
- Oligomeric structure of colicin ia channel in lipid bilayer membranes.The Journal of biological chemistry · 2009Article
- Virus evolution: how far does the double beta-barrel viral lineage extend?Nature reviews. Microbiology · 2008Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orf virus, the prototype parapoxvirus, is responsible for contagious ecthyma in sheep and goats. The central region of the viral genome codes for proteins highly conserved among vertebrate poxviruses and which are frequently essential for viral proliferation. Analysis of the recently published genome sequence of orf virus revealed that among such essential proteins, the protein orfv075 is an orthologue of D13, the rifampin resistance gene product critical for vaccinia virus morphogenesis. Previous studies showed that D13, arranged as "spicules," is necessary for the formation of vaccinia virus immature virions, a mandatory intermediate in viral maturation. We have determined the three-dimensional structure of recombinant orfv075 at approximately 25-A resolution by electron microscopy of two-dimensional crystals. orfv075 organizes as trimers with a tripod-like main body and a propeller-like smaller domain. The molecular envelope of orfv075 shows unexpectedly good agreement to that of a distant homologue, VP54, the major capsid protein of Paramecium bursaria Chlorella virus type 1. Our structural analysis suggests that orfv075 belongs in the double-barreled capsid protein family found in many double-stranded DNA icosahedral viruses and supports the hypothesis that the nonicosahedral poxviruses and the large icosahedral DNA viruses are evolutionarily related.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.